Kyousuke Kasuga is no stranger to being the new kid at school. Despite only being a third-year middle schooler, he has spent his entire childhood avoiding those who discover his family's paranormal powers, and he has had to change schools seven times as a result. Upon catching a beautiful girl's hat, he becomes optimistic and hopes that he and his family have finally moved for the last time. When Kyousuke gets to school, however, he learns a different story. The elegant girl he just met turns out to be none other than Madoka Ayukawa—also known as Madoka the Pick—a delinquent known to smoke, drink, and get into fights. Her best friend is first-year Hikaru Hiyama, a childish and energetic girl who quickly falls in love with Kyousuke. Enamored with both girls, Kyousuke tries to balance a delicate triangle of emotions, all while dealing with the antics brought about by a family with paranormal powers.

After the murder of her father, Ryuuko Matoi has been wandering the land in search of his killer. Following her only lead—the missing half of his invention, the Scissor Blade—she arrives at the prestigious Honnouji Academy, a high school unlike any other. The academy is ruled by the imposing and cold-hearted student council president Satsuki Kiryuuin alongside her powerful underlings, the Elite Four. In the school's brutally competitive hierarchy, Satsuki bestows upon those at the top special clothes called Goku Uniforms, which grant the wearer unique superhuman abilities. Thoroughly beaten in a fight against one of the students in uniform, Ryuuko retreats to her razed home where she stumbles across Senketsu, a rare and sentient Kamui, or God Clothes. After coming into contact with Ryuuko's blood, Senketsu awakens, latching onto her and providing her with immense power. Now, armed with Senketsu and the Scissor Blade, Ryuuko makes a stand against the Elite Four, hoping to reach Satsuki and uncover the culprit behind her father's murder once and for all.

Bundled with the franchise's Kill Me Baby Super Best Album CD (キルミーベイベー・スーパー). OAD adapted eight previously unanimated story episodes from Kazuho's original manga. (Source: ANN)

Peace has returned to Honnouji Academy at last, and now that it has served its original purpose, the unique high school is set to be shut down within a month. However, there is still one final event that must take place: the graduation ceremony. As each member of the student council prepares to leave their past selves behind to focus on what they would like to do in the future, Satsuki Kiryuuin struggles to find her own path, having lost her resolve after finally achieving victory. But just before she is to give her speech to the student body, the ceremony is disrupted by mysterious beings that are identical to the student council members. As Ryuuko Matoi and the Elite Four prepare for battle once more, they quickly discover that the one pulling the strings is an old enemy who has returned to take revenge.