After successfully holding off the invasion by Aftokrator, the Border Defense Agency prepares an away mission into the Neighbor's dimension. However, like in previous scouting expeditions, only A-rank teams are certain to secure a spot. As the B-rank wars continue, Osamu Mikumo and the rest of Tamakoma-2 quickly fight to the top in an attempt to obtain a promotion before the operation begins. Meanwhile, a new Neighbor ship approaches Border Headquarters. Noticing that the attackers are targeting the Border Expedition Ship, forces are hastily sent to combat them. However, with fewer squads available due to the proceeding rank wars, the organization is sent into disarray. This latest offensive from the Neighbors shrouds the fate of the all-important expedition ship in uncertainty.

Akira lnugami is infected with a terrible poison. The only known antidote has an unfortunate side effect-it turns him into a werewolf. He opts for survival but then has to cope with his new desires and with the attention of the military, which is in terested in using his affliction for its own purposes. (Source: The Anime Encyclopedia)

In a dying world, there exists an ancient legend: when the world ends, the gateway to paradise will be opened. This utopia is the sole salvation for the remnants of life in this barren land, but the legend also dictates that only wolves can find their way to this mythical realm. Though long thought to be extinct, wolves still exist and live amongst humans, disguising themselves through elaborate illusions. A lone wolf named Kiba finds himself drawn by an intoxicating scent to Freeze City, an impoverished town under the rule of the callous Lord Orkham. Here, Kiba discovers that wolves Hige, Tsume, and Toboe have been drawn in by the same aroma. By following the fragrance of Lunar Flowers, said to be the key to opening the door to their ideal world, the wolves set off on a journey across desolate landscapes and crumbling cities to find their legendary promised land. However, they are not the only ones seeking paradise, and those with more sinister intentions will do anything in their power to reach it first.

When a gate to another world suddenly opens on Earth, Mikado City is invaded by strange creatures known as Neighbors, malicious beings impervious to traditional weaponry. In response to their arrival, an organization called the Border Defense Agency has been established to combat the Neighbor menace through special weapons called Triggers. Even though several years have passed after the gate first opened, Neighbors are still a threat and members of Border remain on guard to ensure the safety of the planet. Despite this delicate situation, members-in-training, such as Osamu Mikumo, are not permitted to use their Triggers outside of headquarters. But when the mysterious new student in his class is dragged into a forbidden area by bullies, they are attacked by Neighbors, and Osamu has no choice but to do what he believes is right. Much to his surprise, however, the transfer student Yuuma Kuga makes short work of the aliens, revealing that he is a humanoid Neighbor in disguise.