Maria is a powerful young witch living with her two familiars in medieval France during the Hundred Years' War against England. As the war rages on and the innocent get caught in its destruction, Maria becomes fed up with the situation and begins using her magic to try and prevent further conflict in hopes of maintaining peace. However, her constant intervention soon attracts the attention of the heavens, and the archangel Michael is sent to keep her from meddling in human affairs. The divine being confronts Maria, and he forbids her from using her powers, issuing a decree that her magic will be taken if she loses her virginity. Though she is now labeled a heretic, Maria adamantly refuses to heed Michael's warning and continues to disrupt the war between the two nations. But as the Church begins plotting to take away the witch's power and put a stop to Maria's interference once and for all, her peacemaking may soon come to an end.

In search of true love, Kanako Miyamae transfers to Ame no Kisaki Catholic school, inspired by how her parents fell in love with each other there. There is just one difference, though: because men make Kanako break into hives, she has actually come to the all-girls school to find a partner of the same sex. When she meets the beautiful Mariya Shidou, Kanako believes she has found that special someone; however, there's more to Mariya than meets the eye—it turns out that Kanako's first love is actually a cross-dressing boy. Mariya threatens to expose Kanako's impure intentions unless she keeps his real gender a secret, and to make things worse, he also replaces her original roommate so that he can now keep a close eye on her. Maria†Holic follows Kanako as she looks for love in all the wrong places and searches for the girl of her dreams—that is, if she can survive being Mariya's roommate!

The amazing Taichi Keaton works on cases around the globe that always lead to adventure! He combines his arsenal of multidisciplinary expertise in investigation, archeology, and survival with his experience as a professor, a Falklands Conflict veteran and a SAS agent to unravel the often dangerous challenges in each riveting episode. (Source: Geneon Entertainment USA)

A story about a crossdressing teacher handling a delinquent class. Based on the same-name seinen manga by Rin Kasahara.