The exciting antics of Wagnaria return as more ridiculous incidents occur, friendships are deepened, and new feelings are discovered. In addition to Souta Takanashi and his wacky co-workers, more eccentric personalities join the family restaurant: Haruna, Hyougo Otoo's missing wife, who has a habit of getting hopelessly lost through the sewer system; Kirio Yamada, Aoi's older brother, who is able to withstand Mahiru Inami's deadly punches; and twins Youhei and Mitsuki Mashiba, Kyouko Shirafuji's juniors who do not get along. Absurdity, romance, and hilarity are all on the menu for the Wagnaria family restaurant!

Now in his second year of high school, Rei Kiriyama continues pushing through his struggles in the professional shogi world as well as his personal life. Surrounded by vibrant personalities at the shogi hall, the school club, and in the local community, his solitary shell slowly begins to crack. Among them are the three Kawamoto sisters—Akari, Hinata, and Momo—who forge an affectionate and familial bond with Rei. Through these ties, he realizes that everyone is burdened by their own emotional hardships and begins learning how to rely on others while supporting them in return. Nonetheless, the life of a professional is not easy. Between tournaments, championships, and title matches, the pressure mounts as Rei advances through the ranks and encounters incredibly skilled opponents. As he manages his relationships with those who have grown close to him, the shogi player continues to search for the reason he plays the game that defines his career.

Yuusuke Yamamoto has a crippling phobia of women, and understandably so—the twin girls living next door tried to cut off his penis as a child. Unfortunately, Yuusuke's father is a gynecologist and needs him to overcome his fear so he can inherit the family business. To accomplish this, Yuusuke's father offers sanctuary to sisters Rika and Yuka Nakamura in their home while the girls are studying at the nearby college. In a terrible twist of fate, when Yuusuke realizes that their guest room is too small for two people, he is forced to choose which of the sisters is allowed to stay. Desperate to win his favor, the brazen Yuka and the more reserved Rika are willing to do whatever it takes to impress and eventually sway Yuusuke—even if it means making things physical and personal.

Mylene Hoffman, a beautiful cyborg spy with the codename 009-1 lives in an alternative world where the cold war never ended, continuously on-going for 140 years. The world is split into two factions, the West and the East block. A masquerade of peace between the two is slowly dissipated as the conflict occurs. Through politics, the two factions battle over supremacy over technology to threats of a nuclear attack. Mylene Hoffman, teaming up with three other agent, gets surrounded by deception, chaos, and rivalry as she carries out missions assigned by her superiors.