Look! In the sky...It's a bird...It's a plane...It's Super Pig?! One fateful day, Karin, a junior-high student, found what she thought was an injured piglet. However, the piglet was just exhausted from hunger. After the piglet regained his health by eating Karin's apple, he revealed that he is a prince, Tonrariano III, from a planet called Booringo. Tonrariano wanted to reward Karin for helping him and so he transformed her into a pig with superpowers. Karin was not at all pleased with the gift because she wanted to become a pretty superheroine like Cutey Chao (a parody of Cutey Honey), not Super Pig. Reluctantly, she became more interested in her role as Super Pig when she found out that she can turn into someone like Cutey Chao if she can collect 108 pearls through doing good deeds for other people.

Following the original TV series, the story tells the efforts of Momiji Gakuen, Chacha's rival school principal, to discover what is so special about Urara Gakuen students and what she could do to produce the best students.

Shirayuki and Zen Wistalia have finally confirmed their romantic feelings for each other, and everyone has resumed their daily lives. Shirayuki remains an apprentice court herbalist at the royal palace of Clarines, and Zen continues his duties alongside his aides. However, their daily routines are disrupted when Crown Prince Izana, Zen’s older brother, receives an invitation from Raji Shenazard, the prince of Tanbarun. The herbalist finds herself ordered to go to Tanbarun for seven days, to build a new friendship with the formerly selfish and haughty ruler who once ordered Shirayuki to become his concubine. Along the way, Shirayuki is bound to run into trouble once again, as she is sought by a mysterious boy named Kazuki, someone she has never met.

Although her name means snow white, Shirayuki is a cheerful, red-haired girl living in the country of Tanbarun who works diligently as an apothecary at her herbal shop. Her life changes drastically when she is noticed by the silly prince of Tanbarun, Prince Raji, who then tries to force her to become his concubine. Unwilling to give up her freedom, Shirayuki cuts her long red hair and escapes into the forest, where she is rescued from Raji by Zen Wistalia, the second prince of a neighboring country, and his two aides. Hoping to repay her debt to the trio someday, Shirayuki sets her sights on pursuing a career as the court herbalist in Zen's country, Clarines. Akagami no Shirayuki-hime depicts Shirayuki's journey toward a new life at the royal palace of Clarines, as well as Zen's endeavor to become a prince worthy of his title. As loyal friendships are forged and deadly enemies formed, Shirayuki and Zen slowly learn to support each other as they walk their own paths.