The story is set in Nagasaki prefecture in Minami Shimabara city, the fabled origin of the Shimabara Rebellion that sent shockwaves through all of Japan in the early Edo period. It is also where a third-year junior high school student named Shirou spends his days with his school friends. One summer day, Shirou's older childhood friend Akane returns to Minami Shimabara from Tokyo. Shirou and Akane take a stroll around Minami Shimabara with another longtime friend, Tokiya. While these friends are dealing with nostalgia and more complex feelings, a mysterious creature named Goron suddenly appears before them. This encounter with a mere little creature causes great events to unfold once more in this city... (Source: ANN)

During a blizzard, Masayuki Muroi's old high school friend pushes him off a mountain to certain death. However, Masayuki survives the fall and escapes to safety thanks to Yuki-Onna, the spirit of a beautiful young woman who is said to lead men to their demise—but all she asks in return is money. Eleven years later, Masayuki has lived a successful life, having gotten married and amassing a great fortune. But when his company collapses and his wife cheats on him, Masayuki retreats to the city where Yuki-Onna once saved him, and he reconnects with her by offering her money and tasty meals. While Masayuki recovers from his misfortunes, another one knocks on his door: his ex-wife is found beaten to death, and now only Yuki-Onna—who cannot reveal herself—can corroborate his alibi. With no one to turn to, Yuki-Onna enlists the help of the spirits' God of Wisdom, Kotoko Iwanaga. Revered by the various spirits that wander the earth, Kotoko uses her extraordinary wits and cunning to solve all quarrels they may have. In her duty to protect spirits and humans from colliding, Kotoko drags along her immortal boyfriend, Kurou Sakuragawa, and promises to prove Masayuki's innocence without exposing Yuki-Onna's existence.

Rinne Rokudou has bigger problems than going to school—namely, helping spirits pass over to the next life. Because of this responsibility, he often finds himself short on money and struggles to buy his necessities: food, clothes, and exorcism tools. Sakura Mamiya has been able to see ghosts since she was little. She hoped she would outgrow it, but even after starting high school, nothing has changed. To make matters worse, the first time her ever-absent classmate, Rinne, shows up for school, only Sakura can see him. She assumes, as anyone would, that he is a ghost. However, to Sakura's surprise, Rinne proceeds to attend school like normal the next day. Kyoukai no Rinne chronicles Sakura's journey as she learns of Rinne's true nature and the existence of a hidden supernatural world.

Vampires are known to have many weaknesses that balance out their incredible power, but the vampire lord Draluc happens to be weak to pretty much anything. The vampire hunter Ronald receives a job to infiltrate the castle of the so-called Invincible Progenitor and rescue a woman's son from the monster within. But upon arriving, he is dumbfounded to discover that the vampire quickly turns to ash by something as trivial as a clap of his hands! Moreover, the child he was sent to save had merely wandered in to play the vampire lord's video games while he slept! In a disastrous turn of events, Draluc's castle is destroyed, and the fragile vampire decides to move in with the hunter who has only just defeated him. Ronald, Draluc, and the vampire's pet armadillo John form quite the eccentric team as they are forced to work together while fending off Ronald's violent editor, the lesser vampires plaguing the city, and even their fellow vampire hunters.