The great detective Holmes does not solve mysteries or use deductive reasoning. He does, however, hunt vampires. Using three-minute episodes, Vampire Holmes retells the story of the great Holmes and his assistant. What begins as an ordinary detective agency takes a turn for the occult when the Metropolitan Police of London secretly hire Holmes and Hudson to investigate vampires. Or at least that's what Holmes would tell anyone who asks. In reality, he and Hudson spend most of their time sitting around arguing, and failing to solve any cases. Joined by the not-so-black, demon cat Kira, and their terrifying rent-hungry landlady, this is the story of the man who was most definitely not London's greatest detective.

Evil Shinma (shape-shifting monsters and vampires) roam the Earth on a mission to unleash their darkness upon the Human race. Miyu Royal Princess from the dark is the Chosen One—the one being who must banish the Evil Shinma from the Earth. She has the power to offer Humans the gift of eternal happiness, yet is herself, trapped between two worlds; destined for perpetual solitude and internal conflict. Miyu's only companion is Larva, once an evil Shimna; now her devoted guardian. Together they share a dark journey through the weakness of the human heart and the tragic loss of innocence. Cut off from humanity by the knowledge of what she is, Miyu lives an endless quest as both the hunter and the hunted, on the edge of darkness. (Source: AniDB)

10,000 years in the future, the world has become a very different place; monsters roam the land freely, and people, although equipped with high tech weapons and cybernetic horses, live a humble life more suited to centuries past. The story focuses on a small hamlet plagued by monster attacks and living under the shadow of rule by Count Magnus Lee, a powerful vampire lord who has ruled the land for thousands of years. When a young girl is bitten by the Count and chosen as his current plaything, she seeks out help of a quiet wandering stranger, D. It so happens that D is one of the world's best vampire hunters, and he takes it upon himself to cut through Magnus Lee's many minions, and put an end to the Count's rule. (Source: AniDB)

The cheerful Yuuki Cross and the gruff Zero Kiryuu are members of the disciplinary committee at Cross Academy, which houses two very distinct classes: the Day Class and the Night Class. Their job consists of upholding order between the classes when they switch out. While that may not seem like an especially difficult task, the Day Class is unaware of the truth behind the Night Class—their utterly gorgeous students are vampires. Ten years ago, Yuuki was saved from a vampire attack by Kaname Kuran, a Pureblood vampire. Now, Kaname is the leader of the Night Class, and Yuuki's disciplinary committee position allows her to see him again, making her feelings for him grow complicated. Meanwhile, Zero bears a white-hot hatred of all vampires and believes they can never live in harmony with humans. But a secret from Zero's past soon threatens the fragile peace of all at the academy, and things may never be the same again.