Equipped with his passion for diving and admiration for marine biology, university student Tsuneo Suzukawa tries his best to juggle several part-time jobs to earn enough money to study abroad. But one night, in a fateful accident, he meets a girl in a wheelchair, driving his current path into a detour. The girl, Kumiko—who prefers to be called Josee—initially comes off as rude. Tsuneo, however, is then convinced by Josee's grandmother to take on the paid job to be Josee's caretaker. Despite being annoyed with her bossy demeanor, Tsuneo sees the opportunity to save more funds to support his academic dream. Nonetheless, after putting up with Josee's behavior for some time, Tsuneo tries to quit, only to discover Josee's dreams of traversing the outside world—to experience a life free from her crippling condition. Changing his mind, Tsuneo decides to accompany Josee in exploring the wonders that the world has to offer. Through their time together, the two begin to realize that the traits that bind them may be vital toward fulfilling their respective aspirations.

When he was a child and out catching bugs, Jin Mikuriya fatefully encountered a deity, which became the inspiration for his newest piece of art: The Tree Spirit. Trying to think of a way to bring the wooden statue to school, Jin believes that the rest of the day will be spent admiring his work. But before he can even lift it, the sculpture begins to absorb the earth around it and explodes into a cute girl! The girl, Nagi, who introduces herself as a guardian of the earth, proclaims that Jin must help her get rid of the impurities that plague the land. But alas, due to Nagi's tree being cut down and her powers completely drained, she finds herself cleansing the impurities with only a magical wand! With their lives now intertwined, Jin and Nagi find ways to learn more about one another through the endless amounts of daily antics.

Mizuki Usami is a passionate member of her school's art club, but the club has a problem—Usami is the only member who takes her craft seriously! The lazy club president constantly sleeps through activities and Collette hasn't regularly attended club activities in quite some time. Uchimaki Subaru, despite being an exceptional artist who could win an award if he tried, is obsessed with drawing the perfect 2D wife. Light-hearted and comedic in tone, Kono Bijutsubu ni wa Mondai ga Aru! follows Usami as she struggles to do art club-like activities, often obstructed by her motley crew of good-for-nothings and her distracting crush on Subaru.

Ever since her late mother took her to an aquarium when she was young, Tsukimi Kurashita has been obsessed with jellyfish, comparing their flowing tentacles to a princess's white dress. Now living with five other unemployed otaku women, 19-year-old Tsukimi spends her days as a social outcast dreaming of becoming an illustrator. However, her life changes forever when one day, a beautiful woman unexpectedly helps her save a jellyfish in a local pet store. From then on, the stranger—confident, fashionable, and the complete opposite of Tsukimi and her roommates—begins to regularly visit the girls' building. This trendy hipster, though appearing shallow at first, harbors some secrets of her own, starting with the fact that she isn't really a girl at all, but a wealthy male college student named Kuranosuke Koibuchi!