Holo is a powerful wolf deity who is revered in the small town of Pasloe for blessing the annual harvest. Yet as years go by and the villagers become more self-sufficient, Holo has been reduced to a mere folktale. When a traveling merchant named Kraft Lawrence stops at the settlement, Holo offers to become his business partner if he takes her to her northern home of Yoitsu. The savvy trader recognizes Holo's unusual ability to evaluate a person's character and accepts her proposition. Now in the possession of both sharp bargaining skills and a charismatic negotiator, Lawrence inches closer to his goal of opening his own shop. However, as Lawrence travels the countryside with Holo in search of economic opportunities, he begins to realize that his aspirations are slowly morphing into something unexpected.

Ayumu Narumi has lived all his life in the shadow of his famous detective brother, Kiyotaka. However, Kiyotaka disappeared two years ago, leaving behind his wife Madoka and Ayumu himself, along with a cryptic message about the Blade Children. One day, a girl at Ayumu's school suddenly dies. What seemed like a suicide at first glance turns out to be a murder, and Ayumu is the prime suspect. While investigating the person responsible for framing him, he discovers that the mysterious Blade Children are involved—and they somehow know Kiyotaka personally. Ayumu soon finds out just how dangerous the Blade Children are and learns that, in reality, he and Kiyotaka are intertwined more closely than he had ever believed.

Ten years after the Bubble War, the dichotomy between the rich and the poor in the world becomes more prominent and Japan is no exception. The rich seek to satisfy their desires and derive pleasure for themselves, and Tokyo has materialized into such a city as a result. Saiga, once a war photographer, works for Hibara Ginza in the capitalist state of Tokyo. He infiltrates the Roppongi Club, a secretive base located in the red light district of the city, to collect information about them. However, he was caught in the process and brought forward to a girl called Kagura who was in the midst of a ritual. His contact with Kagura awakens his special ability: the power to make things explode when photographed. In order to unravel the mystery behind the Roppongi Club and Kagura, Saiga begins his solitary battle.

Underneath the surface of the Earth lies the Inner World, a realm where a war rages on between intelligent spiders and the invading humanoid insects known as Insectors. However, the spiders are not alone, as Spider Riders—humans from the Outer World, known as Earthens in the Inner World, that are chosen by the Oracle—fight alongside them. Filled with wondrous tales of a mysterious pyramid and entrusted with his grandfather's journal, a young boy called Hunter Steele sets out on an exploration. There, his destined meeting with the Oracle occurs, and he is transported into the Inner World as a Spider Rider. Finding himself lost and confused in the middle of a forest, Hunter crosses paths with a giant spider named Shadow. Although reluctant, Shadow agrees to fight by his side. He then meets Corona—a skilled Spider Hunter and kind girl with a penchant for normal life. She shows him the ropes of being a Spider Rider, and educates him about the fate of the Inner World if the Insectors continue their tyrannical reign. Thus begins the story of Hunter Steele, a heedless young boy on a quest to save the Inner World. But his task of retrieving the four Oracle Keys holding the Oracle's true power will lead him to an ultimate clash against Mantid, leader of the Insectors.