Miz plans to retire as a Great Priestess of Water to married life with her darling Fujisawa and as replacement the young Qawoor Towles arrives to Floristica. Jinnai sees Qawoor's initiation ceremony as a chance to infiltrate Makoto's laboratory but accidentally activates a mysterious thingy that sends them all through the dimensions to a grey industrial city protected by a huge castle in an alternative world. (Source: ANN)

High school science-whiz Makoto Mizuhara is working on his newest project in preparation for the school festival, alongside his best friend Nanami Jinnai. Nanami's brother and Makoto's lifelong rival, the unscrupulous student council president Katsuhiko Jinnai, is under scrutiny for mishandling the school festival planning and is convinced that Makoto is plotting to steal his position. One night, as Makoto and Nanami are taking a break with their teacher Masamichi Fujisawa, Jinnai sneaks into the science lab and sabotages Makoto's device, which suddenly opens a portal that flings all four of them into another world! Upon arrival, Makoto is immediately attacked by a horde of giant bug monsters. While running from them, he comes across Fujisawa and a girl named Rune Venus. After Fujisawa fights off the monsters, a group of dignitaries arrives, looking for Rune, their princess. They inform Makoto and Fujisawa that they are in a world called El-Hazard and take them back to the palace of Roshtaria, their kingdom. Though her advisors are suspicious of the newcomers, Rune decrees that they are to be treated as guests and quickly befriends Makoto. Unaware that Nanami and Jinnai are in this world as well, Makoto gets to work trying to figure out a way back to Earth.

After a routine raid, the rookie sky pirate Coud finds a most unusual cargo in his mates' cargo hold: Ren, an Edel Reid, a race prized by humans for granting special combat power to their partners through Reacting. He quickly discovers, however, that Ren is even more prized than he expected. The pirate ship is visited by three members of the Edel Reid Complete Protection Agency Arc Aire, who try to purchase her. When Coud refuses, the ship is suddenly attacked by a mysterious force, and Coud's captain charges him with Ren's protection. (Source: ANN)

After Makoto Mizuhara agrees to testify against the boisterous student council president Katsuhiko Jinnai for bribing school clubs in the recent student council elections, Jinnai chases him down in an attempt to silence his self-proclaimed rival. Suddenly, during the chase, time stops for everyone—except Makoto. Perplexed, he wanders around the campus until he notices a light coming from the school's closed-off basement, where an ancient relic had just been uncovered. Makoto is walking toward the artifact surrounded by strings of light, when out of it comes an otherworldly woman who claims she has been waiting for ten thousand years to see him. Weakened by the passage of time, she uses her remaining power to transport a confused Makoto to another world, which she refers to as El-Hazard. However, others who are still at school are also caught in the spell, namely: Jinnai; Masamichi Fujisawa, the alcoholic teacher; and Nanami Jinnai, the headstrong sister of president Jinnai. The fantastical and magnificent world of El-Hazard awaits these four individuals where they will become entangled in the story of its inhabitants and embark on an adventure filled with laughter, danger, and even romance.