In the year 19XX, after being betrayed and left for dead, bravehearted warrior Kenshirou wanders a post-apocalyptic wasteland on a quest to track down his rival, Shin, who has kidnapped his beloved fiancée Yuria. During his journey, Kenshirou makes use of his deadly fighting form, Hokuto Shinken, to defend the helpless from bloodthirsty ravagers. It isn't long before his exploits begin to attract the attention of greater enemies, like warlords and rival martial artists, and Kenshirou finds himself involved with more than he originally bargained for. Faced with ever-increasing odds, the successor of Hokuto Shinken is forced to put his skills to the test in an effort to take back what he cares for most. And as these new challenges present themselves and the battle against injustice intensifies, namely his conflict with Shin and the rest of the Nanto Seiken school of martial arts, Kenshirou is gradually transformed into the savior of an irradiated and violent world.

The infamous Shounen Bat is terrorizing the residents of Musashino City. Flying around on his rollerblades and beating people down with a golden baseball bat, the assailant seems impossible to catch—much less understand. His first victim, the well-known yet timid character designer Tsukiko Sagi, is suspected of orchestrating the attacks. Believed only by her anthropomorphic pink stuffed animal, Maromi, Tsukiko is just one of Shounen Bat's many victims. As Shounen Bat continues his relentless assault on the town, detectives Keiichi Ikari and Mitsuhiro Maniwa begin to investigate the identity of the attacker. However, more and more people fall victim to the notorious golden bat, and news of the assailant begins circulating around the town. Paranoia starts to set in as chilling rumors spread amongst adults and children alike. Will the two detectives be able to unravel the truth behind Shounen Bat, or will the paranoia get to them first?

Thrown into solitary confinement after a daring rescue attempt, Jolyne Kuujou fights to uncover the sinister plot of Whitesnake, an enemy Stand whose mysterious wielder remains unknown to her. Whitesnake's user is actually Enrico Pucci, priest and chaplain of Green Dolphin Street Prison. Pucci shares a deep connection with a villain who once plagued the Joestar bloodline, making his feud with Jolyne and her father, Joutarou, a personal one. Intent on executing the master plan of his deceased friend, Pucci uses the prison and its inmates to fulfill his nefarious schemes. Assisted by fellow prisoners, like Ermes Costello and Foo Fighters, Jolyne battles several enemy Stand users. As the ramifications of Pucci's plot spread beyond the confines of the prison and begin to threaten the rest of the world, Jolyne embraces her family lineage and risks her life to put an end to evil.

Crime never sleeps in Roanapur, and neither does Roberta—a devoted maid and skilled guerilla soldier in service to the Venezuelan Lovelace family. After the assassination of her superior by the US Secret Service, Roberta returns to the city of debauchery in search of vengeance and his killer's head. Meanwhile, young Fernando Garcia Lovelace, the new heir to his father's estate, tails Roberta to Thailand alongside his bodyguard, Fabiola Iglesias. He enlists the help of the Lagoon Company, with the objective of deterring Roberta's warpath and bringing her back to the family. However, with the continued bloodshed and mounting tensions between Roberta, island crime factions, and the US military, it will take a significant amount of strategy—and weaponry—to stop her relentless quest for revenge.