Soon after falling into another world, Kurumi Tokisaki takes interest in a particular white cat. Much to Kurumi's disappointment, the two part ways. Kurumi later meets Hibiki Higoromo, a white haired quasi-spirit. Hibiki explains that they are at the center of a killing game between quasi-spirits. Within the Neighboring World, the spirits compete for a single wish to be granted to the lone survivor of the death-match. Understanding the rules of the game, Kurumi and Hibiki reach a compromise—a temporary alliance.

When Shoutarou Tatewaki first meets Sakurako Kujou, he knows his life will never be the same. Initially believing her to be responsible for a disappearance in the neighborhood, he later learns of her true talent: analyzing bone specimens. Sakurako has quite the collection of reconstructed animal bones, but she wishes she had more of the human variety, much to the chagrin of those around her. Soon, Shoutarou begins accompanying the eccentric osteologist on the many different unsolved cases she comes across—usually in the form of decomposing bodies. But with so many incidents happening around them, could there be a larger mystery at work in their lives? Sakurako-san no Ashimoto ni wa Shitai ga Umatteiru is a story of two unlikely partners, each showing in their own way that bones can tell how one died, but only people can tell how they lived.

On a new day in the Kanto region, Satoshi gets invited by Professor Yukinari Ookido over to Professor Sakuragi's lab-opening ceremony in Vermillion City. During the ceremonial speech, Professor Sakuragi receives an alert of a possibly rare Pokémon appearing in Vermillion City's harbor, leading Satoshi and the other trainers to rush to the area in hopes of finding the mysterious Pokémon. At the harbor, they find Lugia—a Legendary Pokémon—engaged in combat with other trainers. Noticing the other trainers' tactics, Satoshi has his partner, Pikachu, strike Lugia with a Thunderbolt attack. Unfazed, Lugia flees, but not before Satoshi determinedly leaps onto its back. To Satoshi's surprise, he meets another boy, Gou, who leapt onto Lugia's back as well. The two ride on Lugia's back as it brings them along on a bizarre adventure across the seas. As it lets the two back on the ground, Satoshi and Gou bid their farewells to Lugia and return to Sakuragi Institute. Impressed by Gou's findings and Satoshi's insight taken during their encounter, Sakuragi requests for the duo to be his new research partners. And so the duo's journey begins, traveling across multiple regions to meet many new Pokémon—including ones that have the ability to Gigantamax!

Mahiro Yasaka is just an ordinary high school student, until one day he is suddenly attacked by a dangerous monster. Just when everything seems to be lost, he is saved by a silver-haired girl named Nyaruko, who claims to be the shape-shifting deity Nyarlathotep from horror author H. P. Lovecraft's Cthulhu Mythos, sent by the Space Defense Agency to Earth. She explains to Mahiro that the creature chasing him was an alien called Nightgaunt, who had planned on abducting and selling him as a slave. After rescuing him from the alien, the Lovecraftian deity falls madly in love with Mahiro and forces herself into his household, much to his chagrin. Moreover, they are soon joined by two others from the fictional universe: Cthuko, a girl obsessed with Nyaruko, and Hasuta, a young boy easily mistaken for a beautiful female. Together, the three eccentric aliens protect Mahiro from the various extraterrestrial dangers that threaten both his and Earth's well-being, all the while making his life a living hell.