There is no putting it lightly—Tsunayoshi Sawada is just no good. He is clumsy, talentless, and desperately in love with the school idol Kyouko Sasagawa, a girl so completely out of his league. Dubbed Loser Tsuna by his classmates, he seems to be the very personification of failure in the guise of a middle-schooler. Tsuna's boring life takes an extraordinary twist when he encounters the mysterious Reborn, who happens to be a hitman... and shockingly, a baby! Sent from the strongest Mafia family in Italy, Reborn is assigned the daunting mission of preparing the dull middle schooler to succeed the ninth boss of the notorious Vongola family, who is on the brink of retirement. The dull boy has a grueling road ahead, but with the help of his new criminal affiliates and his peculiar home tutor, perhaps even Loser Tsuna can achieve greatness.

Having a friend that knows you inside out should be a good thing, but in Nishikata's case, the opposite is true. His classmate Takagi loves to tease him on a daily basis, and she uses her extensive knowledge of his behavior to predict exactly how he will react to her teasing, making it nearly impossible for Nishikata to ever make a successful comeback. Despite this, Nishikata vows to someday give Takagi a taste of her own medicine by making her blush out of embarrassment from his teasing.

The cheerful Yuuki Cross and the gruff Zero Kiryuu are members of the disciplinary committee at Cross Academy, which houses two very distinct classes: the Day Class and the Night Class. Their job consists of upholding order between the classes when they switch out. While that may not seem like an especially difficult task, the Day Class is unaware of the truth behind the Night Class—their utterly gorgeous students are vampires. Ten years ago, Yuuki was saved from a vampire attack by Kaname Kuran, a Pureblood vampire. Now, Kaname is the leader of the Night Class, and Yuuki's disciplinary committee position allows her to see him again, making her feelings for him grow complicated. Meanwhile, Zero bears a white-hot hatred of all vampires and believes they can never live in harmony with humans. But a secret from Zero's past soon threatens the fragile peace of all at the academy, and things may never be the same again.

Izuku Deku'' Midoriya and his fellow students in Class 1-A of UA High's hero course have been chosen to participate in a safety program on Nabu Island. To further improve their skills and gain experience in more ordinary heroics, the students aid the kind citizens with small services and everyday chores. With the low crime rate in the quiet community, all seems well and good, but the rise of a new villain threatens to put the students' courage to the test and challenge their capabilities as heroes. A merciless villain by the name of Nine is in search of a certain quirk needed to fulfill his diabolical plan—creating a society where only those with the strongest quirks reign supreme. As his attack on Nabu Island endangers the lives of the residents, securing the citizens becomes the first priority for Class 1-A; defeating Nine along with his wicked accomplices is also imperative. A straightforward strategy is formulated until a young boy named Katsuma Shimano, whom Deku had befriended, suddenly requires particular protection. Concerned for the boy's wellbeing, Deku and his classmates must now devise a plan to ensure Katsuma's safety at all costs. With Nine wreaking havoc to find the catalyst for his ill-intended schemes and the heroes desperate to defend Katsuma from harm, will Deku and his friends be able to come out victorious, or will they find themselves unable to escape a hopeless situation?