On the brink of extinction, mankind has downsized and now solely resides in the city-state of Flandore, living in cities encased by glass domes. Beyond the domes exist vicious lycanthropes who thrive in the darkness; among the citizens inside, a clear distinction between the nobility and commoners is in place. The blood of nobles enables them to utilize mana, granting them abilities that exceed human limits and greatly assist them in defeating lycanthropes. Already 13 years of age, noble Melida Angel has yet to manifest her mana, and attends an elite academy where she is mistreated for her lack thereof. In order to help her, Kufa Vampir is ordered by the Angel family to become Melida's tutor. While Kufa seems to be a mere mentor, an ulterior motive lurks behind his job—he is to assassinate her if he confirms that she does not possess mana. Kufa's investigation eventually leads him to determine he must eliminate Melida. However, Kufa is struck by her unwavering determination, spirit, and belief in herself when he witnesses her in a fight, choosing instead to offer a way she can manifest her magic. As Melida learns to use mana with the help of Kufa's teachings, Kufa forsakes his mission and jeopardizes everything to keep his discovery of Melida unknown to the Angel family and his own guild. However, both Kufa and Melida will soon realize that hiding their secret will not be the only challenge they face, as unforeseen trouble is waiting just around the corner.

Thwarted again by Naraku, Inuyasha, Kagome Higurashi, and their friends must continue their hunt for the few remaining Shikon Jewel shards, lest they fully form into a corrupted jewel at the hands of Naraku. But Naraku has plans of his own to acquire them, and will destroy anyone and anything standing in his way—even his own underlings. The persistent, unyielding danger posed by Naraku forces Sango and Miroku to decide what is most important to them—each other or their duty in battle. Meanwhile, Inuyasha must decide whether his heart lies with Kikyou or Kagome, before fate decides for him. Amid the race to find the shards, Inuyasha and his brother Sesshoumaru must also resolve their feud and cooperate for their final confrontation with Naraku, as it is a battle they must win in order to put a stop to his evil and cruelty once and for all.

Venturing into the wilderness, the skeptical Ryouta Murakami and the ambitious Kuroneko were on a quest to prove the existence of extraterrestrial life when a tragic accident occurred, reaping Kuroneko of her life and leaving Ryouta in a critically injured state. Ten years have passed since the disaster, and Ryouta is now living a normal life in high school. He vows to prove that aliens are real in honor of his late friend. A transfer student named Neko Kuroha unexpectedly arrives one day, bearing a striking resemblance to the late Kuroneko—even sharing a similar name. Most mysteriously, she seems to possess supernatural powers. As Ryouta takes more interest in Neko, he is drawn into a deadly world where dangerous scientists hunt magic-wielding witches that have escaped from their secret research laboratory. Neko is one of these escapees, but there are many others who are in similar situations, and it's up to Ryouta to protect them from their would-be captors.

For the Takakura family, destiny is an ever-spinning wheel, pointing passionately in their direction with equal tides of joy and sorrow before ticking on to the next wishmaker. With their parents gone, twin brothers Kanba and Shouma live alone with their beloved little sister Himari, whose poor health cannot decline any further. On the day Himari is given permission to temporarily leave the hospital, her brothers take her out to the aquarium to celebrate, where the family's supposed fate is brought forth with her sudden collapse. However, when Himari is inexplicably revived by a penguin hat from the aquarium's souvenir shop, the hand of fate continues to tick faithfully forward. With her miraculous recovery, though, comes a cost: there is a new entity within her body, whose condition for keeping her fate at bay sends the boys on a wild goose chase for the mysterious Penguin Drum. In their search, the boys will have to follow the threads of fate leading from their own shocking past and into the lives of other wishmakers vying for the Penguin Drum, all hoping to land upon their chosen destiny.