Following a catastrophic war against a race of giants known as the Zentradi, humanity has escaped towards the center of the galaxy aboard a fleet of colonial vessels called the Macross Frontier. As the extraterrestrial threat is left further and further behind, life on Macross Frontier proceeds as usual. In the year 2059, a young mecha pilot trainee named Alto Saotome and his colleagues are preparing to perform an accompanying routine for the famous singer Sheryl Nome, who has come to Macross Frontier for a concert. During the performance, a biomechanical alien species known as the Vajra make a sudden appearance, breaking through the defensive perimeter surrounding the vessel and crash-landing near the concert venue, plunging the entire city into chaos. As the concertgoers evacuate, a young girl named Ranka Lee is left behind and gets targeted by the Vajra, but she is saved at the last minute by Alto. Following these events, the Strategic Military Services program notes Alto's skill in battle, resulting in his recruitment to combat the new alien threat.

Aileen Lauren Dautriche's life changes forever on the day her engagement with the crown prince Cedric Jeanne Elmir is nullified so he can be together with Lilia Rainworth. The event triggers Aileen's memories from her past life—she has been reincarnated in an otome game as the villainess, who is destined to die in the final act. To prevent her predetermined demise, Aileen has only one option: to court the game's last boss, Claude Jeanne Elmir—the proclaimed Demon King and Cedric's half-brother—and marry him. However, it is easier said than done, as Claude distrusts her intentions. Instead of giving up, Aileen adamantly tries to win his heart by helping Claude fulfill his wish: to build peace between humankind and demonic beasts. But time is running out, and it is up to Aileen to change the course of not only her tragic ending but Claude's as well.

Self-professed home security guard Mahiro Oyama has not left his home in years, secluding himself in his room playing erotic visual novels. This depraved lifestyle causes his prodigious sister, Mihari, to worry about his well-being. In hopes of solving this problem, she devises a plan to rehabilitate him back to normalcy. The first part of Mihari's plan is to concoct a medicine that changes her brother's biological constitution into a bona fide female, much to Mahiro's vehement dismay. Stuck in this predicament, Mahiro has no choice but to live out his life as a cute girl until the effect wears off—if it ever does.

Third part of Dr. Stone: Science Future.