Shiki Toono wakes up in a hospital ward with the ability to see invisible lines. These thin threads, which make up all matter in Shingetsutan, instantly destroy an object when severed. Shiki discovers that if he traces the lines of something, its destruction soon follows. While keeping his supernatural vision a secret, Shiki proceeds to live his sophomore life in peace. However, this peace is short-lived when Shiki encounters a mysterious woman with bright red eyes on his way back from school. Following a sudden psychotic lapse, he appears to kill the woman, and passes out shortly after. As if things couldn't get any worse, Shiki is assailed by a pair of demonic hounds the next day—facing certain death, Shiki is saved by the timely arrival of the same woman from yesterday. She introduces herself as Arcueid Brunestud, a vampire princess. Deciding to team up, Shiki and Arcueid embark on a journey to uncover the truth behind their lineage and the recent string of murders around town.

The young but feared sorcerer Zagan is a candidate to become a member of the 13 Archdemons—a group of the strongest sorcerers in the world—following the death of their eldest member, Marchosias. When attending the deceased Archdemon's estate auction, Zagan finds something he did not expect: love at first sight. The sorcerer impulsively spends all his money to take Nephelia, a rare elf slave, back to his castle. Given the girl's mysterious and troubling past, there is a lot for Zagan to uncover about his new companion. However, Zagan's lack of experience with the unfamiliar feeling of love leads to many awkward moments between him and Nephelia, whom he calls by the nickname Nephy. As the two grow closer and get more comfortable around each other, it becomes increasingly evident that Nephy's feelings might not be so different from Zagan's.

The previously bedridden Keina Kagami finds herself in the world of her favorite VRMMORPG—titled Leadale—after the life support keeping her alive fails. Reincarnated in the body of her high-level character, Cayna, she notices that the world of Leadale is different from what she remembers playing. As she comes to learn, two hundred years have passed since she last interacted with the world. However, this does not sadden Cayna—as it means that a new journey awaits her, filled with exciting prospects and unfamiliar faces all waiting to be discovered.

When loner Touka Mimori is summoned to another world alongside his classmates, he obtains the power to inflict status ailments, such as paralysis or poison, on his enemies. Unfortunately for him, skills of this nature are considered useless due to their low success rate, and Touka is thus assigned the title of E-rank hero. Things take a further turn for the worse when Vicius, the goddess who summoned the class, reveals that the lowest-ranked hero will be disposed of so that they do not hinder those with greater talent. Banished to a notoriously dangerous area, Touka comes face-to-face with death after being cornered by a minotaur-like creature. In a desperate attempt to survive, he uses his supposedly worthless skill—only to quickly realize that it works almost every time. Armed with the ability to render the monsters standing in his way completely helpless, Touka resolves to track down the goddess that tossed him aside and exact his revenge.