When five students at Yamaboshi Academy realize that there are no clubs where they fit in, they band together to form the Student Cultural Society, or StuCS for short. The club consists of: Taichi Yaegashi, a hardcore wrestling fan; Iori Nagase, an indecisive optimist; Himeko Inaba, a calm computer genius; Yui Kiriyama, a petite karate practitioner; and Yoshifumi Aoki, the class clown. One day, Aoki and Yui experience a strange incident when, without warning, they switch bodies for a short period of time. As this supernatural phenomenon continues to occur randomly amongst the five friends, they begin to realize that it is not just fun and games. Now forced to become closer than ever, they soon discover each other's hidden secrets and emotional scars, which could end up tearing the StuCS and their friendship apart.

Seven years after the defeat of Majin Buu, Earth is at peace, and its people live free from any dangers lurking in the universe. However, this peace is short-lived; a sleeping threat awakens in the dark reaches of the galaxy: Beerus, the ruthless God of Destruction. Disturbed by a prophecy that he will be defeated by a Super Saiyan God, Beerus and his angelic attendant Whis search the universe for this mysterious being. Before long, they reach Earth and encounter Gokuu Son, one of the planet's mightiest warriors, and his powerful friends.

One day, the bright red sun stopped shining, causing the Breakdown Phenomenon—the destruction of Arata Kasuga's town and the disappearance of the people inhabiting it. All, however, is not yet lost; by utilizing the magical grimoire given to him by his childhood friend and cousin Hijiri Kasuga, Arata's world gets artificially reconstructed. In order to investigate the phenomenon, Lilith Asami appears before Arata, whose artificial world suddenly disintegrates. He is given two choices: hand over the book, or die. However, Arata chooses the third option—enrolling in the top-secret magic school Royal Biblia Academy, where six other magical users await him. Together with Lilith, these six form the Trinity Seven, the elite of the school who each bolster their own power and skill. With the ambition to save Hijiri and the help of his newfound friends, Arata stops at nothing to prevent the destruction of his beloved hometown and to bring his best friend back.

Naho Takamiya's first day of her sophomore year of high school is off to an uneasy start. After waking up late, she receives a strange letter addressed to her. However, the letter is from herself—10 years in the future! At first, Naho is skeptical of the note; yet, after witnessing several events described to take place, she realizes the letter really is from her 26-year-old self. The note details that Naho's future life is filled with regrets, and she hopes that her younger self can correct the mistakes that were made in the past. The letter also warns her to keep a close eye on the new transfer student, Kakeru Naruse. Naho must be especially careful in making decisions involving him, as Kakeru is not around in the future. With the letter as her guide, Naho now has the power to protect Kakeru before she comes to regret it once more.