World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.

Taito has been really sleepy lately, and keeps dreaming of a female vampire who says she has given him her poison. Sometimes he even thinks he hears her voice when he's awake. But after surviving an accident that should have killed him, Taito's world changes drastically and he realizes that his dreams are more real than he thought.

Poor Shinichirou Asano has the worst of luck. His parents abandoned him and ran off to Europe. If that isn't bad enough on its own, they barely left him any money to take care of himself. In order to pay rent and keep a roof over his head, he has to work. Unfortunately, he was just fired from his last job and as a high school student, he doesn't have many other prospects. One evening, he's attacked by a centipede monster on his way home. Shinichirou is saved by a mysterious girl with a bow and arrow, who he later discovers is Sakuya Shimazu, a beautiful student who attends his school. But when he later helps an injured girl, he discovers two things. First, the injured girl isn't human at all but rather a nekomata, a two-tailed demon cat. And second, Sakuya comes from a family of exorcists, who've protected humanity from rogue monsters and spirits for generations. Because Shinichirou was responsible for releasing the nekomata, Sakuya enlists his help in recapturing the demon, but that's just the beginning of Shinichirou's relationship with Sakuya. It turns out the Shimazu family needs a housekeeper and it just so happens that Shinichirou excels at cooking and likes to clean! It may not be his dream job, but if it pays the rent and puts food on the table...

After an enthusiastic invitation from her friend, Kaede Honjou reluctantly agrees to try New World Online: a very popular VRMMO played by thousands of people across Japan. Naming her in-game character Maple, she sets out on her journey. As a complete novice to such games, she allocates all of her stat points into vitality, desiring to not get hurt. With not a single point in any other stat, Maple has extraordinarily high defense, but she can't move quickly or hit hard. This does not end badly for her, however. Due to her high defense, Maple acquires overpowered skills such as Total Defense, Poison Immunity, and Devour. These skills, along with the incredibly powerful items she obtains, allow her to obliterate most enemies in a single hit. After only a few days of playing the game, Maple claims third place in a server-wide event, gaining a reputation as a player who is both unkillable and absurdly powerful. Despite her overpowered character, Kaede has much to learn. As she progresses through the game, she meets new friends and acquaintances, helping her complete new levels and events. Through all of her adventures, she may even pick up some other crazy skills that exceed all expectations.