With World War II right around the corner, intelligence on other countries' social and economic situation has become a valuable asset. As a result, Japan has established a new spy organization known as the D Agency to obtain this weapon. Under the command of Lieutenant Colonel Yuuki, eight agents have been assigned to infiltrate and observe some of the most powerful countries, reporting on any developments associated with the war. In order to carry out these dangerous tasks, these men have trained their bodies to survive in extreme conditions and studied numerous fields such as communications and languages. However, their greatest strength lies in their ability to manipulate people in order to obtain the information necessary to give their nation the upper hand.

Every 12 years, mercenaries who possess the highest caliber of brute strength, cunning wit, and deadly precision gather to participate in the Zodiac Tournament. Each warrior bears the name and attributes of one of the 12 animals of the Chinese zodiac. With their pride and lives on the line, they engage in vicious combat until only the victor remains. The 12th Zodiac Tournament begins in a desolate city, devoid of any evidence of the half million people who recently lived there. To raise the stakes, each warrior ingests a poisonous gem, thus setting a time limit on the tournament—and on their life. With one wish for the victor up for grabs, the Zodiac Warriors start their cutthroat battle for survival.

As another school year begins drawing to a close, the third-year high school students move steadily toward the next milestone of their lives: graduation. Among them are Mio Natsume, a girl burdened with lingering feelings; Hazuki Morikawa, a member of the concert band but distant from the others; and Haruto Souma, an athlete obsessed with baseball. Meanwhile, second-year student Ena Komiya seeks to revive the photography club to its former glory, refusing to let the organization be disbanded. Though this group lacks a strong connection with one another, their lives suddenly cross paths with the arrival of a third-year transfer student. While a transfer so close to graduation is unusual for most, it is business as usual for Eita Izumi. Due to his father's work, he has never been able to stay in one place for very long. But as luck would have it, their most recent relocation has returned Eita to his hometown for his final semester of high school. For better or worse, it also sparks the rekindling of old relationships left behind in the past. With graduation already causing its own share of anxieties, Eita's sudden arrival brings these students' carefree days to an abrupt end. Long-forgotten memories, deeply buried emotions, and inspiring new passions—everything is brought to light in their bittersweet final semester.

A spin-off chibi anime of Kage no Jitsuryokusha ni Naritakute!.