The village of Ootsuka—home to Shino Inuzuka, Sousuke Inukawa, and Hamaji—was lit on fire under the preconception that a virus had seen all of its life eradicated. Now surrounded by flames and on the verge of death, the three were approached by a strange man holding a sword. He tells them that they must reach a decision if they want to live. That night changed everything for these children. Five years later, the family of three now lives under the watchful eye of the small Imperial Church in a nearby village. All is fine and dandy until the Church attempts to reclaim the demonic sword of Murasame. To accomplish this, they kidnap Hamaji to lure Shino, now a bearer of Murasame's soul, and Sousuke, who possesses the ability to transform into a dog. The brothers must put their differences aside to rescue their beloved sister from the Church in the Imperial Capital, signalling the beginning of a very difficult journey.

Ohana Matsumae is an energetic and wild teenager residing in Tokyo with her carefree single mother. Abruptly, her mother decides to run away with her new boyfriend from debt collectors, forcing the young girl to fend for herself—as per her mother's rely only on yourself philosophy—in rural Japan, where her cold grandmother runs a small inn. Driven to adapt to the tranquil lifestyle of the countryside, Ohana experiences and deals with the challenges of working as a maid, as well as meeting and making friends with enthralling people at her new school and the inn.

Haré's family receives a video letter from Weda's home in the city. Witnessing how sad and lonely Weda's mother and Bel are without her, Weda decides to take Haré and Guu back to the city for a while. After Haré complains about being bored and lonely without his friends in the jungle (as part of his plot to persuade his mother to take him back), Weda decides to send him to a private school in the city, where he instanly falls in love with a pretty girl named Rita. But, of course, Guu wants part of the action too. (Source: ANN)

Haré was a happy boy living out his days in the jungle with his mother, but then one day Guu showed up and became a member of their household. Throughout the series he faces many hardships as he tries to keep Guu out of trouble in the jungle. (Source: ANN)