Abandoned as a child by her mother, Aoi Tsubaki has always had the ability to see ayakashi—spirits from the Hidden Realm. Shirou Tsubaki, her grandfather who shared the same ability, took her under his wing and taught her how to live with the ayakashi in peace. When her grandfather abruptly passes away, the independent Aoi must continue her college career, armed with only her knowledge in cooking as a means of protection against the human-eating spirits. In hopes that the ayakashi will not turn to her or other unknowing humans as a tasty meal, she takes it upon herself to feed the hungry creatures that cross her path. After giving a mysterious ayakashi her lunch, Aoi is transported to the Hidden Realm, where the ayakashi reveals himself to be an ogre-god known as Oodanna, the Master Innkeeper. There, she learns that she was used as collateral for her grandfather's debt of one hundred million yen, and that she must pay the price for her grandfather's careless decision by marrying Oodanna. Aoi valiantly refuses and decides to settle things on her own terms: she will pay off the debt herself by opening an eatery at Oodanna's inn. Kakuriyo no Yadomeshi follows the journey of Aoi as she proceeds to change and touch the lives of the ayakashi through the one weapon she has against them—her delicious cooking.

Since reincarnating into a new world, Ryouma Takebayashi has used his god-given graces to tame countless slimes and employ them to improve the lives of everyone around him. With the astonishing success of his laundry shop, Bamboo Forest, he is finally ready to take on new frontiers and open a branch in the neighboring city of Lenaf. Abiding by his promise with his dearest friend, Eliaria Jamil, Ryouma makes every day count, whether learning new techniques, forming connections, or even discovering more species of slime.

Deep in the forest, far from any human contact, there lives a child named Ryouma Takebayashi. He engages in the rather strange hobby of keeping various types of slimes as pets. Furthermore, despite his young age, he has a sturdy physique and good compatibility for magic. All of this is because, having endured much hardship in his previous life, three gods grace Ryouma with a second chance to pursue one goal: savor the wonders of life. After three years of comfortable solitude pass by, Ryouma meets people that will change his current life forever. When he encounters and helps some soldiers tend to their wounded comrade, the group convinces him to accompany them to visit the nearby town's ducal family. Ryouma agrees and soon embarks on a journey to explore the vast world beyond his home.

A few young girls with strange powers and a tree that has grown through a railcar cling onto life in a desolate land, searching for its last reservoirs of water. Their routine struggle to survive is interrupted by the arrival of Wakaba, a boy with no memory beyond his own name. The girls and their new companion commit to a perilous journey across seas of burning red fog—all in order to find what they need to sustain themselves on the more distant, dangerous islands swarming with robotic bugs. Their ultimate fate will be decided by their own strength, along with Wakaba's curious ability to understand the Kemurikusa: mysterious glowing leaves with wondrous powers. Besides the girls, Wakaba, and the hordes of ravenous bugs, the Kemurikusa are the last sparks of life surviving in this land. How did things end up this way? Why are there so many empty buildings with no one to live in them? Wakaba and the girls lack the answers to these questions, which means the truth can only be found within the Kemurikusa.