Ayakashi are strange, supernatural creatures invisible to the majority of people. Though most are harmless, some ayakashi attack humans to devour their life force. Exorcist ninjas are tasked with protecting people from these spiteful spirits. Matsuri Kazamaki is a young exorcist ninja born to a prestigious clan. His childhood friend, Suzu Kanade, is an ayakashi medium—an individual with immense vitality that attracts ayakashi. Matsuri deems all ayakashi threatening and wishes to keep Suzu as far from them as possible, but this clashes with her desire to remain close to them. One day, the pair encounters Shirogane, the King of Ayakashi, who is hellbent on consuming Suzu. As she is about to be eaten, Matsuri comes to the rescue and manages to seal the ayakashi's powers—but not before Shirogane takes revenge by turning him into a girl! Until he finds a way to transform back, Matsuri must adjust to his new, peculiar lifestyle while fighting against hostile ayakashi. Moreover, Suzu is now conflicted about her feelings toward Matsuri—further plunging their relationship into a state of ambiguity.

Kaoruko Chaos Moeta is a young manga artist who is down on her luck. She wants to draw manga about high school girls, but her storyboards are bland, her art uninspired, and her premises weak. Her concerned, exasperated editor comes up with an idea: push Chaos to be more social. So, by her recommendation, Chaos moves into a dormitory for female manga artists. She soon meets the other residents: Tsubasa Katsuki, a shounen manga artist; Ruki Irokawa, who draws erotic manga popular with women; and Koyume Koizuka, a shoujo artist who, like Chaos, has yet to be serialized. Quickly striking up a friendship with these girls, Chaos finds new inspiration for her manga and continues to grow her creativity. Comic Girls is a showcase of the daily lives of these manga artists. Will Chaos finally be able to make her debut and become serialized? None of the girls know, but they will all do their best to help each other become the best artists they can be.

Within Cardia Beckford's hazy memories, she can recall her father Isaac and the home where she lives alone, feared as a monster by the townsfolk—for in her body, she carries a deadly substance. Embedded in her chest by her father, the eternally beating heart—also known as Horologium—has the capability to produce infinite power. However, it also makes her skin destroy anything it touches. Many in London seek the Horologium, including the terrorist organization Twilight, with whom Isaac is rumored to have close ties. To obtain the Horologium's power, the British military forces Cardia to leave her home as their prisoner. But on the road, she is whisked away by the gentleman thief Arsène Lupin, who says he will steal her heart. Joining Lupin and his companions, Cardia begins a journey to discover the truth behind Isaac's connection with Twilight, her missing memories, and the Horologium within her chest.

Keita Amano is a typical high school gamer living out an average student's life. One day, however, he has an unexpected meeting with the cutest girl in school that makes him want to disappear without a trace! This girl, Karen Tendou, is an exemplary student who is proclaimed to be the school's idol. She discovers that Amano is a gamer, and this newfound knowledge incites a passionate desire within her to recruit him into the game club. Upon visiting the club, Amano is forcefully made aware of a side to gaming wildly different than the one he loves so dearly. Tendou's interest in Amano begins shaking up what was once an uneventful life, filling it with spontaneity, awkwardness, and a little bit of mayhem. As a result, every day becomes a comical battle for Amano's sanity as he tries to adapt to these wild, unexpected changes.