Reiji Kirio, formerly a corporate slave, wakes up one day in another world. After discovering that he has gained superhuman pharmaceutical knowledge, he decides to open up a drugstore alongside the canine Noera and the ghostly Mina. There, he tends to the needs of all who visit the shop with potions and the like. Cheat Kusushi no Slow Life: Isekai ni Tsukurou Drugstore follows the slow but often hectic days of Reiji's drugstore.

Ken Usato, an ordinary high schooler, wishes for something fantastical to occur in his unremarkable life. Such an opportunity arrives when he is transported to another world alongside Kazuki Ryuusen and Suzune Inukami, two prodigious members of his school's student council. Arriving in Llinger Kingdom, the three are deemed to be the heroes tasked with stopping the impending invasion by the Demon Lord's army. However, this is a misunderstanding—Usato was summoned by accident and, unlike his two friends, is not one of the heroes. Despite this disheartening revelation, Usato learns that he has an aptitude for the extremely rare healing magic. This catches the attention of Rose, the intimidating captain of the kingdom's Rescue Team, who forcibly takes custody of Usato to mold him into a full-fledged healer. As he undergoes grueling training under Rose's supervision, Usato resolves to become capable enough to protect his friends from the dangers of this world.

A powerful necromancer known as the Corpse God dies during a legendary battle, only to be reborn as Polka Shinoyama, a young boy in modern-day Tokyo. In the process of trying to adapt to his new physical body, he gets targeted by various groups that deal with the supernatural. Among them is Misaki Sakimiya, a high school girl who can see spirits and is out for his blood from the very moment they meet. Attempting to make sense of this situation where unknown parties want him dead, Polka eventually meets Takumi Kuruya, a contractor skilled in surveillance and hacking, and Lisa Kuraki, a crime boss operating out of Shinjuku. Alongside these—and other unexpected—allies, Polka braves danger to reveal the truth of his reincarnation and the fate awaiting the world he now lives in.

In the distant future, the cities of Japan have been walled off and isolated from one another. Tourism and immigration are heavily controlled—if not impossible. Each region is overseen by an AI moderator that maintains its domain as it sees fit. These clusters are refined into a single ideal, with every citizen fulfilling their role in preserving the moderator's creation. But not everyone is satisfied with the narrowly focused vision of the city they were born in, and thus, they require some under-the-table help in relocating to a more appropriate cluster. During the day, Equa, Ferres, and Martese are ordinary high school students; but at night, they act as Extractors—people who illegally smuggle civilians between the city borders. Transporting those brave enough to leave everything behind, Equa and her friends risk their lives in order to give their clients a second chance. But the dangers of extraction begin to intensify when the cluster moderators become increasingly aware of the group's actions that threaten their perfect utopias.