Kae Serinuma is a very kind second-year high school student and a devoted otaku. A little known fact about her, though, is that she's obsessed with BL, or Boy's Love. Serinuma can't help but to fantasize about her male classmates falling for each other and enjoys imagining them together. A more known fact about Serinuma, however, is that she’s noticeably overweight. While watching her favorite show one day, Serinuma witnesses the death of her most beloved character. Utterly depressed, she can't muster up the energy to eat her meals, let alone attend school. After an entire week, she finally recovers. But now there's something unusual about her—during the time she refused to leave her room, she ended up losing a large amount of weight and has somehow become strikingly beautiful! Now catching the eye of everyone who sees her, she finds herself at the center of attention of four boys she has always known at her school. Though they all wish to spend time with her, Serinuma would much rather they spend time falling in love with one another. How will Serinuma deal with the four boys pursuing her BL-obsessed self?

After living 50 simulated high school lives and dating over 100 virtual boys, Tomoko Kuroki believes that she is ready to conquer her first year of high school. Little does she know that she is much less prepared than she would like to think. In reality, Tomoko is an introverted and awkward young girl, and she herself is the only one who doesn't realize it! With the help of her best friend, Yuu Naruse, and the support and love of her brother Tomoki, Tomoko attempts to brave the new world of high school life. Watashi ga Motenai no wa Dou Kangaetemo Omaera ga Warui! chronicles the life of a socially awkward and relatively friendless high school otaku as she attempts to overcome her personal barriers in order to live a fulfilling life.