It is the dark century and the people are suffering under the rule of the devil, Vandel, who is able to manipulate monsters. The Vandel Busters are a group of people who hunt these devils, and among them, the Zenon Squad is known to be the strongest busters on the continent. A young boy, Beet, dreams of joining the Zenon Squad. However, one day, as a result of Beet's fault, the Zenon squad was defeated by the devil, Beltose. The five dying busters sacrificed their life power into their five weapons, Saiga. After giving their weapons to Beet, they passed away. Years have passed since then and the young Vandel Buster, Beet, begins his adventure to carry out the Zenon Squad's will to put an end to the dark century.

Ichiko Sakura lives life on easy mode. Blessed with good fortune, she has everything she has ever wanted, including beauty, intelligence, and wealth. Momiji Binboda is a goddess of poverty. In stark contrast to Ichiko, she is cursed with misfortune, such as a perpetual cast on her arm, a flat chest, and a box under a bridge for a home. Their lives collide when Momiji lives up to her title and delivers some unfortunate news to Ichiko: her large amount of luck is due to her subconsciously draining the luck from those around her! Momiji has been tasked with stealing back Ichiko's fortune before she leaves everyone without enough luck to even survive. But Ichiko, with the help of the wandering monk Bobby Statice, manages to fight off the poverty goddess. This defeat forces the goddess to enlist reinforcements in the form of Kumagai, her teddy bear familiar, and the masochistic dog god, Momoo Inugami. Insanity ensues as Ichiko's quiet life is replaced with daily battles for her fortune. To survive the chaos, Ichiko will need all the luck she can get in Binbougami ga!!

The day before her birthday, Akane is asked to retrieve her birthday present from her aunt Chi's shop. While looking around, she chances upon a mysterious slab with a hand-shaped cavity in it. Curious, she places her hand in it, and—to her surprise—it fits perfectly. The next thing she knows, a strange alchemist named Hippocrates and his apprentice Pipo appear, calling Akane the legendary Goddess of the Green Wind. The two eccentrics claim to be from a different world connected to the shop's basement. With the peace of their world in jeopardy, Hippocrates and Pipo seek the help of the only one capable of saving it from destruction: Akane. Forced to accompany them on a journey to restore the land's harmony, Akane—with her aunt in tow—sets off to discover a magical new place.

On the first day of junior high school, Mato Kuroi happens to run into Yomi Takanashi, a shy, withdrawn girl whom she immediately takes an interest in. Mato tries her best to make conversation with Yomi, wanting to befriend her. At first, she is avoided, but the ice breaks when Yomi happens to notice a decorative blue bird attached to Mato's phone, which is from the book Li'l Birds At Play. Discovering they have a common interest, the two form a strong friendship. In an alternate universe, the young girls exist as parallel beings, Mato as Black★Rock Shooter, and Yomi as Dead Master. Somehow, what happens in one world seems to have an effect on the other, and unaware of this fact, the girls unknowingly become entangled by the threads of fate.