Young detective Sonia Summers has been transferred to the outskirts of the port city Libra after stirring up trouble with her superiors. Libra is separated into two sectors—the Upper, the center of wealth and politics, and the Outside. The Outside is home to crime, corruption, and curious incidents involving monstrosities or youkai. Each case that Sonia works on seems to implicate the involvement of these mysterious creatures. Sonia crosses paths with three peculiar humanoid youkai—Bem, Bela and Belo—who seek to protect humans and fight against the evil youkai that terrorize them. Living as Youkai-Ningen, they are excluded by other youkai for their human-like lifestyles, and rejected and hurt by humans when they reveal their true forms. Despite the hardships they face, these three Youkai-Ningen secretly live among humans, continuing to pursue their dreams of one day becoming human as well.

Based on COLOPL's school action role-playing game. Set in the year 2045. The world has been contaminated by Irousu (mysterious invaders who suddenly appeared), and humans find themselves restricted and contained. Standing boldly against these invaders are ordinary girls everywhere, without a powerful army or even weapons. The Shinjugamine Girls Academy is a school for these Hoshimori (Star Guardians) destined to fight the Irousu. The player is assigned to this academy to train the girls and take back the contaminated Earth. And so, once again, the chimes echo through the sun-strewn schoolyard to mark the beginning of classes today... (Source: ANN, edited)

Staz Charlie Blood is a powerful vampire who rules the Eastern district of Demon World. According to rumors, he is a bloodthirsty and merciless monster, but in reality, Staz is just an otaku obsessed with Japanese culture and completely uninterested in human blood. Leaving the management of his territory to his underlings, Staz spends his days lazing around, indulging in anime, manga, and games. When Fuyumi Yanagi, a Japanese girl, accidentally wanders through a portal leading into the demon world, Staz is overjoyed. But just as he is starting to feel an unusual attraction to her, his territory is attacked, resulting in Fuyumi's untimely death. She turns into a wandering ghost and the crestfallen Staz vows to resurrect her as this would mean being able to travel to the human world, something he has always dreamed of. Blood Lad follows Staz and Fuyumi, soon joined by the spatial magician Bell and the half-werewolf Wolf, as they travel to find a magic that can bring humans back to life.

Ryouta Sakamoto is unemployed and lives with his mother, his only real achievement being that he is Japan's top player of the popular online video game Btooom! However, his peaceful life is about to change when he finds himself stranded on an island in the middle of nowhere, with a small green crystal embedded in his left hand and no memory of how he got there. To his shock, someone has decided to recreate the game he is so fond of in real life, with the stakes being life or death. Armed with a bag full of unique bombs known as BIM, the players are tasked with killing seven of their fellow participants and taking their green crystals in order to return home. Initially condemning any form of violence, Ryouta is forced to fight when he realizes that many of the other players are not as welcoming as they may seem. Teaming up with Himiko, a fellow Btooom! player, they attempt to get off of the island together, coming closer and closer to the truth behind this contest of death.