Based on COLOPL's school action role-playing game. Set in the year 2045. The world has been contaminated by Irousu (mysterious invaders who suddenly appeared), and humans find themselves restricted and contained. Standing boldly against these invaders are ordinary girls everywhere, without a powerful army or even weapons. The Shinjugamine Girls Academy is a school for these Hoshimori (Star Guardians) destined to fight the Irousu. The player is assigned to this academy to train the girls and take back the contaminated Earth. And so, once again, the chimes echo through the sun-strewn schoolyard to mark the beginning of classes today... (Source: ANN, edited)

Staz Charlie Blood is a powerful vampire who rules the Eastern district of Demon World. According to rumors, he is a bloodthirsty and merciless monster, but in reality, Staz is just an otaku obsessed with Japanese culture and completely uninterested in human blood. Leaving the management of his territory to his underlings, Staz spends his days lazing around, indulging in anime, manga, and games. When Fuyumi Yanagi, a Japanese girl, accidentally wanders through a portal leading into the demon world, Staz is overjoyed. But just as he is starting to feel an unusual attraction to her, his territory is attacked, resulting in Fuyumi's untimely death. She turns into a wandering ghost and the crestfallen Staz vows to resurrect her as this would mean being able to travel to the human world, something he has always dreamed of. Blood Lad follows Staz and Fuyumi, soon joined by the spatial magician Bell and the half-werewolf Wolf, as they travel to find a magic that can bring humans back to life.

Ryouta Sakamoto is unemployed and lives with his mother, his only real achievement being that he is Japan's top player of the popular online video game Btooom! However, his peaceful life is about to change when he finds himself stranded on an island in the middle of nowhere, with a small green crystal embedded in his left hand and no memory of how he got there. To his shock, someone has decided to recreate the game he is so fond of in real life, with the stakes being life or death. Armed with a bag full of unique bombs known as BIM, the players are tasked with killing seven of their fellow participants and taking their green crystals in order to return home. Initially condemning any form of violence, Ryouta is forced to fight when he realizes that many of the other players are not as welcoming as they may seem. Teaming up with Himiko, a fellow Btooom! player, they attempt to get off of the island together, coming closer and closer to the truth behind this contest of death.

It has been 50 years since mankind began its migration to the terraformed Mars, where they live in comfort due to advancements in AI. Carole lives in the metropolis of Alba City, working part-time by day and playing keyboard by night. Tuesday has run away from her home in Hershell City to escape the grip of her wealthy family, and instead hopes to pursue music with her acoustic guitar. After a fateful encounter, the two decide to perform music together. Up against the AI singers that dominate the music world, the two of them believe that together they can convey their feelings through their songs. Will hard work and luck be enough for the duo to create the biggest miracle that Mars has ever seen?