The tropical Seiren Island is a paradise for deviants: the infamous Pervert Law grants near-complete sexual freedom with almost no taboos or boundaries. With its various suggestive attractions, the Seirantou Health Organization (SHO) entices visitors while providing regular medical checks and contraceptive pills to ensure carefree enjoyment. However, for high school student Junnosuke Tachibana, the island is far from ideal. Having recently moved there with his younger sister, Asane, he cannot stand the empty, loveless sexual acts. To make matters worse, Junnosuke's abstinence attracts unwanted attention—and those who defy the law face punishment. Junnosuke soon crosses paths with Nanase Katagiri, a notorious island seductress. Surprisingly, instead of forcing herself on him, she helps him flee from the SHO. Together, they discover a secret group that exists for a singular goal: to destroy the SHO. Now equipped with a way to resist the unjust rules, Junnosuke and other kindred spirits set out to crush the Pervert Law.

With a cartload of fur pelts in tow, traveling merchant Kraft Lawrence stops by the village of Pasloe. According to local folklore, centuries ago, one of the villagers made a promise with the wolf deity Holo, who swore to bless Pasloe with bountiful harvests of wheat. Yet, as time passed, such stories became little more than relics of the past. After quickly finishing his business in the village, Lawrence sets out to his next destination. His journey, however, takes an unexpected turn when he discovers a nude, animal-eared girl sleeping among his pelts. Even more surprisingly, the youthful-looking woman claims to be Holo—the wolf of legend. Holo wishes to return to her hometown in the north, and though their first encounter is rocky, she convinces Lawrence to accompany her on her travels. In return, she vows to earn her keep, using her quick wits and lifetime of experience to help her newfound companion in his dealings. As they continue their journey, Lawrence and Holo take advantage of whatever economic opportunities they come across, often landing in situations that put both their business skills and their relationship to the test.