Having a friend that knows you inside out should be a good thing, but in Nishikata's case, the opposite is true. His classmate Takagi loves to tease him on a daily basis, and she uses her extensive knowledge of his behavior to predict exactly how he will react to her teasing, making it nearly impossible for Nishikata to ever make a successful comeback. Despite this, Nishikata vows to someday give Takagi a taste of her own medicine by making her blush out of embarrassment from his teasing.

With the initiation of the Patrian civil war came the creation of half-beast, half-human soldiers—a development of the outnumbered Northerners in a desperate attempt to counter the overwhelming Southern forces. Able to quickly dominate battlefields and achieve victory with ease, the soldiers' godlike abilities earned them the name Incarnates. However, as the war raged on, the Incarnates encountered a problem involving the beasts inside them that they were unable to rectify by ordinary means. Once the war was over, mysteries and accounts of the Incarnates submitting to the misfortune of their war days surfaced. Aware of the horrors they faced during the war, Special Sergeant Major and former captain of the Incarnates Hank Henriette becomes a Beast Hunter—those who take the lives of Incarnates who have succumbed to the issues they experienced on the battlefields. After witnessing her father, a former Incarnate soldier, meet his end at the hands of one such Beast Hunter, Nancy Schaal Bancroft resolves to hunt the man who took her father's life. However, Nancy's eye-opening encounter with the Beast Hunter influences her to instead seek the reason behind her father's death and the Incarnates' problematic existence in society.

He is charming, cool, athletic, a good cook, but more importantly, he's a clean freak. Aoyama is idolized and respected by everyone, but they can only admire him from afar due to his mysophobia. Despite that, he plays soccer—a rather dirty sport! As the playmaker for Fujimi High School's soccer club, Aoyama avoids physical contact at all cost and cleanly dribbles toward victory. However, the path to Nationals will not be easy for Fujimi's underdog team. But alongside striker Kaoru Zaizen, Aoyama will show everyone that even as a clean freak, there are things he's willing to get dirty for.

Mitsuha Miyamizu, a high school girl, yearns to live the life of a boy in the bustling city of Tokyo—a dream that stands in stark contrast to her present life in the countryside. Meanwhile in the city, Taki Tachibana lives a busy life as a high school student while juggling his part-time job and hopes for a future in architecture. One day, Mitsuha awakens in a room that is not her own and suddenly finds herself living the dream life in Tokyo—but in Taki's body! Elsewhere, Taki finds himself living Mitsuha's life in the humble countryside. In pursuit of an answer to this strange phenomenon, they begin to search for one another. Kimi no Na wa. revolves around Mitsuha and Taki's actions, which begin to have a dramatic impact on each other's lives, weaving them into a fabric held together by fate and circumstance.