Nozomu Itoshiki is a high school teacher so pessimistic that even the smallest of misfortunes can send him into a pit of raging despair; some of these catastrophes even lead to suicide attempts. Sayonara Zetsubou Sensei is a satirical slice-of-life comedy set in the modern day, covering various aspects of Japanese life and culture through Nozomu and his interactions with his students: Kiri Komori, a recluse who refuses to leave the school; Abiru Kobushi, an enigma who frequently arrives to class with severe and mysterious injuries; the hyper-optimistic Kafuuka Fuura, Nozomu's polar opposite; and several other unusual girls, all of whom are just as eccentric as their teacher.

Haruka Tsuchiya is a plain and simple university student who has a pet by the name of Okojo-san. Okojo-san was actually born in one of the mountains in the North and brought to one of the pet shops to be sold. Determined to get out of the pet shop, Okojo-san formulated an escape strategy and ended up in the house of Haruka. There are always funny and strange occurances happening around the two, be it the people or animals who are near them. This is a gag anime in which absurdity is the main feature of the story. (Source: ANN)

Years ago there was an underground match between Pro Wrestling and Nanshin Shadow Stlye (a secret and deadly form of martial arts) to see which form of martial arts was dominant, The Nanshin Shadow style came out victorious in the battle. Now in the present, the man who was defending Pro-Wrestling is back and is out to destroy Nanshin Shadow style in any way he can; however, it is now up to Kiichi, the son of the previous victor to defend the name of Nanshin Shadow style and it is his job to keep it from being completely erased from existance. (Source: ANN)

The year is 2023 and Alien Beings known as Lucifer Hawks have begun invading earth from another dimension. All that stands between them and the enslavement of the human race is the Attacked Mystification Police Department - a special division of the Tokyo Police staffed by women with amazing paranormal abilities. (Source: ANN)