After Ichiro Ogami's departure at the end of Sakura Taisen 3, the girls of the Paris Flower Defense Force are left debating who will be the next captain. Meanwhile, a centuries-old threat surfaces. (Source: ANN, edited)

New York City, the late 1920s. The battle with Nobunaga is over, the city restored to peace...until the owner of Little Lip Theater informs Shinjiro... This time, the leading lady will be...you. Thus Shinjiro, disguised as the actress Petitmint, is forced into the role of Cleopatra. The Star Division members set out to persuade a reluctant Shinjiro, beginning a chase across the five boroughs. Meanwhile, a dark-skinned youth and his servant have appeared unexpectedly in the midst of the flourishing city. His eyes, concealing a silent wrath, are fixed upon nothing less than the Statue of Liberty. Now Shinjiro and company must protect this city of hopes and dreams from a new menace while safely raising the curtain on a new show. (Source: ANN)

In a post-apocalyptic Earth, the water has become entirely toxic, except for some kept safe in a reservoir. A fortified zone has been created by a man named Sanga, he calls it The Lastland. A group of villagers have discovered safe water, and Sanga wants it. He and his band of killers go to kill everyone and steal it. As they do a mysterious man appears out of nowhere, instantly killing some of Sanga's men. His name is Kenshiro, and he can beat any man with his martial art, Hokuto Shin Ken. Sanga will do anything for the water, and Kenshiro will do anything to try and stop him. (Source: ANN)

In 1941, one year after the defeat of Sotetsu Genan, captain Seijuurou Kamiyama of the Imperial Combat Revue's Flower Division in Tokyo leaves on a secret mission, with Sakura Amamiya temporarily assuming command. Following an incident in Europe, Kamiyama takes a young Russian girl named Klara M. Ruzhkova and leaves her in the Flower Division's care. However, Moscow Combat Revue captain Valery Kaminski is sent to Tokyo to retrieve Klara and the Flower Division must stop him. (Source: Wikipedia, edited)