Otaku siblings Tamotsu and Niwaka Denkigai are shopping in Akihabara when it is overrun by vampiric cosplaying monsters! These creatures, known as Bugged Ones, can possess anyone they bite and soon they begin causing mayhem across the city. As Tamotsu finds himself at the mercy of one of these creatures, he is rescued by the mysterious baseball bat-wielding Matome Mayonaka. Together, they fight through several more encounters with the Bugged Ones, but before long, Tamotsu is fatally wounded protecting Matome. With no other choice, she revives him as a high level Bugged One—just like her! Tamotsu and Matome, along with excitable otaku cosplayer Arisa Ahokainen, make up the group The Electric Mayonnaise and they begin dispatching the Bugged Ones in the only way they know how: by ripping off their clothes and exposing them to sunlight!

For centuries, the Iga and Kouga ninja clans have engaged in a bitter war. But when a ceasefire is ordered by the powerful warlord Ieyasu Tokugawa, the two clans are forced to put down their arms. Years later, Gennosuke Kouga, heir of the Kouga clan, and Oboro Iga, heir of the Iga clan, have fallen in love. Through marriage, both heirs aim to bring peace to the clans. But their hopes are dashed when flames of rivalry between their clans are reignited, and they are dragged into another war. Ieyasu's two grandsons have both claimed to be the next heir to the shogunate. To resolve this dispute, both the Kouga and Iga are ordered to send their 10 best warriors to fight in a bloody battle royale, with each clan representing one of the potential shogunate heirs. Two scrolls with the names of the fighters are given and are to be marked in blood upon the given fighter's death. The prize for winning is the favor of the Tokugawa shogunate for a thousand years. Torn between their love for each other and duty to their clans, Gennosuke and Oboro must ultimately decide the fate of their clans.

Modern Germany is plagued by an outbreak of Amalgams. Existing solely to wreak havoc, these cybernetic entities spawn from rotting flesh and can fuse with technology to gain new abilities. With society left in the wake of their destruction, the Xenogenesis Assault Team (XAT) is formed to suppress the threat. Alongside its primary mission to protect against the Amalgam attacks, the organization is also researching the newly discovered amalgamated humans which possess rational thought and are far deadlier than their non-sentient counterparts. Joseph Jobson is one such amalgamated human who has full control over his powers. Although successful in his line of work as a lone warrior, an unfortunate encounter with the recently-turned-Amalgam Gerd Frentzen makes him a priority target of the XAT. As he eludes the organization and seeks new allies, Joseph is transformed into the Blassreiter—a being heralded as the strongest Amalgam in existence. Now, he must fight back with his newfound powers to uncover the truth behind not only his past, but also the entire Amalgam conflict.

Twenty years prior to the story's beginning, an asteroid headed for Earth destroys Pluto. Due to Pluto's destruction, the asteroid, which is dubbed Thanatos, becomes temporarily stagnant. Now, in order to avoid Earth's impending destruction, the International Solarsystem Development Agency (ISDA) works on the D-Project, and creates the Dragonaut after finding a dragon egg under the ocean. This weapon's primary purpose is to destroy the asteroid when the time comes. However, they soon find out that the asteroid is not their only threat, as powerful dragon-like creatures, which are bent on destruction, appear on Earth. After witnessing a murder by one of the creatures, Jin Kamishina, a lonely 18-year-old boy who lost his family in a shuttle accident two years ago, gets involved in the mysteries of the dragons and becomes the chosen pilot of the Dragonaut. Helping him on his journey is Toa, a mysterious girl who saves him from falling to his death after the creature attacks him. As they get deeper into the mysteries of the dragons, they encounter new friends and enemies, and also begin to develop a closer relationship. (Source: Wikipedia)