Kenjaku, the one known as Noritoshi Kamo and most recently as Suguru Getou, has initiated the next step in his destructive, thousand-year plan of ordinary humans' evolution and eventual eradication. The jujutsu world higher-ups reinstate 15-year-old Yuuji Itadori's execution, as Satoru Gojou is incapacitated as a result of Kenjaku's master plan in Shibuya. While Yuuji is unaware of this, he patrols the abandoned Tokyo streets with Chousou, exterminating any and all cursed spirits in his way. Meanwhile, the bigoted and arrogant Naoya Zenin's pride takes a hit when Megumi Fushiguro is selected as the Zenin Clan's next head. To draw out Megumi and eliminate him, he goes after Yuuji—but Yuuta Okkotsu is set on being Yuuji's executioner. Kenjaku's Culling Game—a rigorous battle royale spanning throughout Japan and forcing the jujutsu competitors to kill each other—is set in motion, and the young jujutsu sorcerers join the fray to settle old scores, free Gojou, and liberate the jujutsu world from the threat that is Kenjaku.

The year is 2006, and the halls of Tokyo Prefectural Jujutsu High School echo with the endless bickering and intense debate between two inseparable best friends. Exuding unshakeable confidence, Satoru Gojou and Suguru Getou believe there is no challenge too great for young and powerful Special Grade sorcerers such as themselves. They are tasked with safely delivering a sensible girl named Riko Amanai to the entity whose existence is the very essence of the jujutsu world. However, the mission plunges them into an exhausting swirl of moral conflict that threatens to destroy the already feeble amity between sorcerers and ordinary humans. Twelve years later, students and sorcerers are the frontline defense against the rising number of high-level curses born from humans' negative emotions. As the entities grow in power, their self-awareness and ambition increase too. The curses unite for the common goal of eradicating humans and creating a world of only cursed energy users, led by a dangerous, ancient cursed spirit. To dispose of their greatest obstacle—the strongest sorcerer, Gojou—they orchestrate an attack at Shibuya Station on Halloween. Dividing into teams, the sorcerers enter the fight prepared to risk everything to protect the innocent and their own kind.

Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.

Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.