Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.

Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.

Even after spending a considerable amount of time with Takagi, Nishikata is still struggling to find a perfect plan to defeat the expert teaser. A battle of wits, a contest of physical prowess, a test of courage—any strategy he employs to expose her weaknesses is to no avail. On the contrary, Nishikata's pitiful attempts only reveal more of his own flaws, which Takagi takes advantage of to become increasingly daring in her teasing attempts. To make things worse for Nishikata, rumors about him and Takagi may have spread in class due to the frequent interactions between them. However, the optimistic Nishikata believes that wisdom comes with age and that as the days go by, his experience with her constant teasing will eventually bear fruit, leading him to the awaited moment of victory. Thus, Nishikata continues to strive for the seemingly impossible—to outsmart Takagi and make her blush with embarrassment.

As summer break comes to an end, Nishikata is stoked to try out his newest pranks and finally outdo his classmate Takagi once and for all. Despite his losing streak, he is slowly getting to know the unrelenting workings of her crafty mind. However, he soon realizes that Takagi's motivations behind her teasing may not be what he initially assumed. One thing is certain, though: each fun-filled day of strategizing and competing brings the two closer than ever.