Two and a half years after the dark day of the Lost JuLai, Meryl Stryfe roams in the desert wilderness of Noman's Land alongside her younger assistant, Milly Thompson. She still pursues Vash the Stampede, the culprit behind the cataclysmic events that took the lives of 90 percent of the JuLai city population. Vash, also referred to as the Humanoid Typhoon, is now sought after for 60 billion double dollars—the largest bounty in the history of the planet. In a backwater town of Noman's Land, an apathetic Vash has been rescued and cared for by Hoppered the Gauntlet, a man who covers his mutilated body with armor. But Hoppered's secluded life is abruptly interrupted by the arrival of young Jessica seeking help for her endangered home.

A squid-like creature, known as a Happian, leaves his home planet with the desire to spread happiness across the universe. He lands on Earth, but quickly finds himself in danger of captivity by its inhabitants. Fortunately, he is found by an unsmiling little girl named Shizuka Kuze, who feeds him and names him Takopii. Feeling indebted, Takopii decides to do everything in his power to bring a smile to her face. The task is easier said than done, however. Shizuka is bullied by her classmates, she does not have a father, and her mother is never home—though the gravity of these issues flies over the naive Takopii's head. Even so, Shizuka does have one source of happiness: her dog Chappy. The connection Shizuka and Chappy share only increases Takopii's desire to make the girl smile. While Takopii's attempts to lift Shizuka's spirits lead to unintended consequences, he is determined to take things into his own tentacles, test his understanding of human beings, and achieve his goal of spreading happiness.

To their classmates, Wada is a quiet rich girl while Yamamoto is an intimidating lone wolf...but what they don't know is that Wada is a mobile game addict in a passionate love-hate relationship (with a 2D character), and Yamamoto has a penchant for urban legends with eyes only for her favorite YouTuber. And their biggest not-so-secret secret—these unlikely friends meet at the food court every day after school to rant, rave, and learn what makes each other tick! (Source: Yen Press)

Ron Kamonohashi, the best student in the history of the elite Detective Training Academy BLUE, has been living as a recluse since BLUE expelled him five years ago. Moreover, he is forbidden to work as a detective, having barely escaped execution after getting involved in a murder case while he was still attending the school. Ron's situation changes drastically when police detective Totomaru Isshiki, following the advice of a senior colleague, seeks him out for help with a criminal case that has remained unsolved for months. Ron reluctantly agrees to help Totomaru and uses his phenomenal intuition to discover the culprit in less than a day. However, it appears that Ron suffers from a mysterious condition that can cause those around him to lose their lives. To Ron's great surprise, Totomaru manages to save the life of someone whom Ron put in jeopardy. As the unlikely duo starts solving crimes one after another, BLUE sends operatives after its former student to find out if he has resumed investigative work. Fighting against murderers, rogue detectives, and the Metropolitan Police Department, Ron and Totomaru must join forces if they want to survive and see justice prevail.