Dr. Kenzou Tenma, an elite neurosurgeon recently engaged to his hospital director's daughter, is well on his way to ascending the hospital hierarchy. That is until one night, a seemingly small event changes Dr. Tenma's life forever. While preparing to perform surgery on someone, he gets a call from the hospital director telling him to switch patients and instead perform life-saving brain surgery on a famous performer. His fellow doctors, fiancée, and the hospital director applaud his accomplishment; but because of the switch, a poor immigrant worker is dead, causing Dr. Tenma to have a crisis of conscience. So when a similar situation arises, Dr. Tenma stands his ground and chooses to perform surgery on the young boy Johan Liebert instead of the town's mayor. Unfortunately, this choice leads to serious ramifications for Dr. Tenma—losing his social standing being one of them. However, with the mysterious death of the director and two other doctors, Dr. Tenma's position is restored. With no evidence to convict him, he is released and goes on to attain the position of hospital director. Nine years later when Dr. Tenma saves the life of a criminal, his past comes back to haunt him—once again, he comes face to face with the monster he operated on. He must now embark on a quest of pursuit to make amends for the havoc spread by the one he saved.

Absent-minded schoolgirl Yoriko Kusumoto only has eyes for Kanako Yuzuki. After planning for their summer trip, their journey comes to a premature and brutal end when Kanako is found severely wounded on train tracks and Yoriko in tears on the station's platform. Shuutarou Kiba, a detective who happened to be on the train that hit the girl, takes up the investigation. However, he discovers that the mystery behind this case is intertwined with an intricate network of deceptions involving the Yuzuki family, especially its most prominent member, Youko Yuzuki—a famous actress and Kanako's sister. Although Kanako survives after surgery, her critical state prompts Youko to entrust a doctor, Dr. Koushirou Mimasaka, to take care of the girl in an ominous, box-shaped facility in the forest where she will receive experimental treatment. But soon after, on a night where Kiba and Yoriko visit Kanako, the convalescent suddenly vanished. Now searching for her whereabouts, the burden on Kiba dramatically grows when he learns about other gruesome discoveries: limbs of young girls in boxes. Kiba is suggested by a colleague that the macabre findings are related not only to Kanako's disappearance but also to the truth behind her sister. As the investigation continues, the detective—enlisting the help of his partners Tatsumi Sekiguchi and Akihiko Chuuzenji—has to find a way to solve this series of crimes and find Kanako back.

Justy Ueki Tylor is an average 20-year-old man: lazy, greedy, and a passionate womanizer. He plans to land an easy job with the United Planets Space Force that pays decently and is also far away from the rigorous combat raging throughout the galaxy. However, Tylor's dreams of living a simple life are brought to a sudden halt when he stumbles into a dangerous hostage situation. Through one strange mishap after another, Tylor miraculously manages to save the hostages and is awarded command of the decrepit space-cruiser Soyokaze! Now Tylor finds himself in charge of sending mad mercenaries, proud pilots, skeptical colleagues, and harsh commanders through the infinite expanse of the universe, all the while avoiding the looming threat of the Holy Raalgon Empire. What misadventures await the irresponsible Captain Tylor?

Departing from their respective hometowns, two young women with identical names are brought together in their pursuit of new beginnings. With their hearts set on going to Tokyo, Nana Komatsu dreams about blissful love, while Nana Osaki aims for a successful music career. The former has a cheerful and friendly nature, but her naivety has steered her romantic life astray until she meets her dependable boyfriend—Shouji Endo. Without letting herself be dismayed by Shouji's decision to study in Tokyo, Nana works hard to earn enough money and follow him there. Meanwhile, her namesake is a solitary punk vocalist whose impassioned romance with her band's bassist, Ren Honjou, comes to a sudden end. Though heartbroken, Nana bravely looks forward and travels to the capital with the ambition of becoming a recognized artist. Shortly after they arrive in Tokyo, the girls cross paths again due to an unexpected coincidence that ultimately leads them to live under the same roof. As they grow closer, the two strive to support one another amid their struggles to forge a future for themselves.