Twenty-two-year-old Eikichi Onizuka—ex-biker gang leader, conqueror of Shonan, and virgin—has a dream: to become the greatest high school teacher in all of Japan. This isn't because of a passion for teaching, but because he wants a loving teenage wife when he's old and gray. Still, for a perverted, greedy, and lazy delinquent, there is more to Onizuka than meets the eye. So when he lands a job as the homeroom teacher of the Class 3-4 at the prestigious Holy Forest Academy—despite suplexing the Vice Principal—all of his talents are put to the test, as this class is particularly infamous. Due to their utter contempt for all teachers, the class' students use psychological warfare to mentally break any new homeroom teacher they get, forcing them to quit and leave school. However, Onizuka isn't your average teacher, and he's ready for any challenge in his way. Bullying, suicide, and sexual harassment are just a few of the issues his students face daily. By tackling the roots of their problems, Onizuka supports them with his unpredictable and unconventional methods—even if it means jumping off a building to save a suicidal child. Thanks to his eccentric charm and fun-loving nature, Class 3-4 slowly learns just how enjoyable school can be when you're the pupils of the Great Teacher Onizuka.

Shaped by experiences that left him weary of human relationships, Rei Hitoma openly dislikes people. Seeking a quiet, uneventful life, he accepts a teaching position at a secluded school in the mountains, only to discover that his classroom is anything but ordinary. The students under his care are demi-humans who have gathered there with a singular goal: to learn what it means to become human. Despite his disillusionment, Rei finds himself responsible for explaining human behavior and social norms to mermaids, bunnies, werewolves, and the like. As his students earnestly struggle to understand humanity, their questions and aspirations gradually expose the contradictions in Rei's own beliefs.

After a brutal surprise attack by the forces of Quincy King Yhwach, the resident Reapers of the Soul Society lick their wounds and mourn their losses. Many of the surviving Soul Reaper captains train to battle without their Bankai, the ultimate technique wielded by the fiercest warriors. In the previous assault, Ichigo Kurosaki narrowly managed to help fend off Yhwach's fearsome wrath. However, to ultimately defeat his godly adversary and save his allies, Ichigo must now undergo severe training that will push him beyond his physical, emotional, and mental limits. Though Yhwach already holds the upper hand in this ongoing blood feud, he also successfully recruits Uryuu Ishida, Ichigo's close friend and rival, to be his successor. Yhwach strikes out once again at the weakened Soul Society, intent on finally obliterating his long-standing enemies. As Ichigo struggles to attain new power, the Soul Reaper captains fight for survival and borrowed time.

After an awe-inspiring battle with Ichibei Hyousube—leader of the Soul Society's Royal Guard—the powerful Yhwach moves into the final stage of his master plan. He aims to slay the Soul King, the being whose very existence maintains the status quo of three worlds: Hueco Mundo, the Soul Society, and the realm of humans that Ichigo Kurosaki and his closest friends hail from. Conquering his own bout with the remainder of the Royal Guard, Uryuu Ishida joins Yhwach in his efforts to create a new world in his image. With a flood of resolution and newfound power, Ichigo rushes to stop Yhwach from accomplishing his ultimate goal and save the countless lives within the three existing realms. But Ichigo has a complicated lineage, one that leaves him susceptible to Yhwach's sinister influence. Meanwhile, in a final desperate gambit, Jirou Sakuranosuke Shunsui Kyouraku, the newly promoted head captain of the Soul Society's combat corps, enlists the help of an old enemy whose immense power may turn the tide of battle.