Megalo Box is an advanced form of boxing where competitors wear metal frames called Gear. When the first ever Megalonia tournament took place, Gearless Joe became its champion and known to all as a legendary fighter. However, soon after, he lost an exhibition match against the second champion and vanished from the public eye. Seven years later, Joe now goes by Nomad and keeps a low profile, occasionally fighting in a few underground matches to get by. He is haunted by hallucinations and relies on a set of painkillers to numb his mind. During a match, Joe wins against an opponent, Chief, who purposefully loses for some extra cash from gamblers. Subsequently, Joe discovers that Chief is from a community of immigrants called the Casa. Chief is gradually trying to make enough money to purchase the land where they live illegally. At first, Joe hesitates to get involved, but eventually decides to lend the Casa a helping hand.

The Noblesse Cadis Etrama di Raizel, also known as Rai, is enrolled in Ye Ran High School by his servant Frankenstein to stay hidden from the sights of the Union, a mysterious organization out for Rai's blood. Rai commences his life as a student, making himself familiar with his classmates and the daily activities of humans. However, his new life is far from peaceful, and Rai is soon forced to save his new friends from the hands of the Union that had abducted them. Meanwhile, M-21—a Union agent gone rogue during Rai's rescue operation—joins the Ye Ran High School security staff after a proposition by the school's director, who happens to be none other than Frankenstein himself. On the surface, M-21 is a prim and proper employee, but in truth he is shackled by his former ties to the Union and the inevitable consequences of betraying the organization. To further complicate matters, Nobles Regis K. Landegre and Seira J. Loyard enroll in the same school to investigate the Noblesse. While the Union conducts a manhunt for M-21 to extract clues regarding their missing agents, Rai is forced to keep his identity hidden while protecting all that he holds dear.

Haruka Nogizaka is the most popular student in the prestigious Hakujo Academy, possessing unparalleled beauty, talent, and influence. Unbeknownst to her fellow students, however, she keeps an embarrassing secret of being an otaku—something that can potentially destroy her elegant reputation. Unfortunately for Haruka, an encounter with the timid Yuuto Ayase in the school library spells the end of her well-kept secret. However, the two reach a mutual agreement with Yuuto promising to keep Haruka's secret, sparking an unexpected friendship between them. Nonetheless, with Haruka's status as the school celebrity and her friendly relationship with Yuuto, both of them are bound to be the subject of gossip everywhere they go!

1. Funshitsu / Miko-san 2. Oshigoto / Henbou 3. Sentou / Service