Touta Konoe is an ordinary boy raised in a small rural town. His mundane life suddenly changes when his mentor, Yukihime, reveals herself to be a vampire; after saving Touta from a mortal wound, she causes him to become immortal as well. Already yearning to explore the world, young Touta finally puts his dream to ascend to the top of Amanomihashira—a tower that leads to outer space—into realization. Along the way, he finds a secret society filled with immortals just like him called UQ Holders. Gaining new comrades and mentorship along the way, Touta embarks on his own unique, magical adventure.

Lupica, another one of the legion of space princesses that all seem to have found out about Earth in some tour book, appears and abducts Ataru! But Lupica isn't after Ataru for his great looks or charming personality (because he doesn't have either). Lupica's goal is the greatest love potion in the galaxy, which she intends to use to induce her sweetheart to tie the knot. To get it, she needs the possessor of the greatest lust in the universe... (Source: AniDB)

The anime centers on the members of the real-world four-member male vocal unit Urashimasakatasen. Uratanuki, Shima, Tonari no Sakata, and Senra appear in the shorts as high school students. (Source: ANN)

Kaori Sasaki—a member of Uchihama Academy's Astronomy Club—confesses to Sou Akiyama, but later that evening, she dies in a tragic road accident. Her friends and fellow club members mourn her death in a local hospital. Yet she shows up to school the following day, and no one senses anything amiss. The day finishes without any unusual incidents, and the group of friends plans for the upcoming cultural festival. Suddenly, the room is shaken by an unnatural earthquake. Everyone splits up to investigate—except for Nagisa Hanamiya, who stays behind. As everyone leaves, Nagisa notices that the odd relic-like cube that she was toying with starts emitting a strange blue light. Meanwhile, Sou stumbles upon an unconscious, naked girl lying in a pool of water. Ushinawareta Mirai wo Motomete follows the Astronomy Club's increasingly bizarre adventures—from dealing with ghosts to quelling unrests between student clubs. All the while, they unravel the circumstances behind the sudden appearance of a new transfer student.