Nobita Nobi is a normal fourth grade student. This all changes, however, when a blue robotic cat appears from his desk drawer. Calling himself Doraemon, this robot tells Nobita that his future descendants from the 22nd century live in poverty because of all the mistakes he made. Therefore, they have sent Doraemon to serve as a guide and mentor to Nobita, so that their future may change for the better. What Doraemon comes to learn, though, is that Nobita is the weakest and laziest student in the whole school. To assist in his quest, Doraemon has a four-dimensional pocket with him, in which he keeps various machines and gadgets from the future. Unfortunately, these often result in even more trouble for Nobita. Will Doraemon really be able to achieve his mission of changing Nobita, or will he remain as he is?

Eager to know why her best friend’s boyfriend dumped her for a man, the headstrong Eiya Arakawa suggests a meeting with them. Gathered together at a café, Yuuga Oota agrees to answer Eiya’s questions only if she can correctly ascertain the relationship of a couple sitting across from them, which she does on her first attempt. Amazed by her astounding intellect and intuition, he invites her to a private meeting where he introduces her to the concept of Slave Control Method, or SCM, a retainer-like device that has the ability to turn people into slaves. When two SCM users enter a duel, the devices exert a powerful influence on their brains. Once the duel is over, the SCM amplifies the loser’s sense of obligation and forces them to bend to the will of the winner. Wanting desperately to test his own abilities, Yuuga asks Eiya to act as his insurance in the event that he himself becomes a slave. Granted access to 10 million yen, Eiya’s job is to convince Yuuga’s would-be master to free him from his servitude. Though hesitant at first, Yuuga’s words resonate with her personal yearning for something more from her life, and she agrees to his request. However, when a mysterious organization begins rapidly accruing slaves, Eiya becomes entangled in a game far more dangerous than she ever could have imagined.

To aid his conquest of Japan, the ruthless lord Daigo Kagemitsu offers to sacrifice his soon-to-be-born son to 48 demons. The demons accept, and the next day, the child is born with several missing limbs and is ruthlessly cast down a river. Fifteen years later, a stubborn young boy named Dororo struggles to survive against hunger and oppressive samurai on the streets of an impoverished and war-torn village. After angering a group of thugs, Dororo is attacked by them, but a mysterious man interrupts them, claiming to hear spirits nearby. Sure enough, a monster emerges from the river, and the man then removes his prosthetic arms, revealing blades hidden underneath, with which he slays the monster before leaving. That night, as the man walks through the forest, Dororo approaches him and declares that he will accompany him. From this, the man, Hyakkimaru, reveals that many of his body parts were stolen by demons and that though he sought a peaceful life, he couldn't escape their relentless onslaught. Despite the tale, Dororo still insists on tagging along. And thus, Hyakkimaru travels through Japan with his new companion and a puppy named Nota, facing the brutality of both hell and mankind.