Taking place in a very distant in future, the adventure begins when a boy meets a certain girl. The Pan Galaxy Republic has declined and so have many empires. This resulted to people in the galaxy being scattered. Living in the peaceful side of their world, Banjou, who picks up trashes at the spherical wall met a girl, frozen, in a broken spaceship. There are bad guys who chase her, and thus, the quiet galaxy suddenly became lively. Little did he know that the frozen girl is Goza 168th, the key to decide the destiny of the whole universe. Overcoming hardship, the two embarks on a trip to make the Galaxy Republic alive again. It may be a difficult challenge, but it's alright, let's progress slowly! A comedy of irresponsible galaxy trip begins! (Source: MAL News)

Mushi-uta's story takes place in the near future. Ten years before the story's opening, strange insect-like creatures known as Mushi began appearing. The Mushi are able to consume peoples' dreams and thoughts in return for supernatural powers. At the end of episode one, protagonist Daisuke Kakkou Kusuriya encounters a young girl named Shiika Anmoto. The two, in time, become quite close. However, unbeknownst to Kakkou, Shiika is an escapee from a secret prison known as GARDEN where those posessed by the Mushi, known as the Mushitsuki are held. GARDEN's military force, the Special Environmental Conservation Executive Office, dispatches its finest killer to track down Shiika. However, they are faced with resistance from the Mushibane resistance organisation, led by the secretive Ladybird. (Source: ANN)

In 1973, following the ruthless six-year-long Lunar War, the hostile alien species known as the BETA—Beings of Extra Terrestrial origin which are Adversary of the human race—invaded Earth, killing billions and decimating Eurasia. While BETA can be destroyed with conventional weapons, their laser-class is able to wipe out entire aircraft fleets, forcing mankind to develop giant combat suits called Tactical Surface Fighters (TSF) to combat them. When the BETA reach Japan in 1998, military school student and TSF pilot—or eishi—Yui Takamura is ordered to defend Kyoto's last line of defense with her fellow classmates. At the cost of countless human lives and the sacrifice of Yui's friends, the Japanese Imperial Army manages to repel the invaders, leaving destruction in its wake. However, this encounter leaves Yui determined to never again allow something like this to occur. Three years later, now a lieutenant, Yui joins the XFJ project, an Alaska-based Japan-American TSF development program. In an international team composed of the uncooperative Japanese-American test pilot Yuuya Bridges and various eishi from countries lost to the BETA, Yui's task is to help develop the new Japanese TSF Shiranui. Amidst political tensions inherited from the Cold War, Muv-Luv Alternative: Total Eclipse follows Yui's delicate mission and Yuuya's journey to overcome the demons of the past that still haunt him.

Souzou Haran was a brilliant scientist that was conducting research on Mars. He created a form of cyborg life with the ability to think for itself. These cyborgs, dubbed the Meganoids, soon ran out of control and killed Dr. Haran along with his whole family, save his youngest son, the 16-year-old Banjou Haran. Banjou escapes from Mars on a rocket with a solar-powered super robot called Daitarn 3, which was built with the special metals of Mars. Now eighteen years old and living on Earth in a luxurious mansion, Banjou fights against the Meganoids with the aid of his faithful butler Garrison and his two gorgeous companions Reika and Beauty. Together they must stop the evil Meganoids which aspire to turn all humans into cyborgs and thus improve the human race. (Source: AniDB)