In the light of day and in the dead of night, mysterious horrors await in the darkest shadows of every corner. They are unexplainable, inescapable, and undefeatable. Be prepared, or you may become their next victim. Sit back in terror as traumatizing tales of unparalleled terror unfold. Tales, such as that of a cursed jade carving that opens holes all over its victims' bodies; deep nightmares that span decades; an attractive spirit at a misty crossroad that grants cursed advice; and a slug that grows inside a girl's mouth. Tread carefully, for the horrifying supernatural tales of the Itou Junji: Collection are not for the faint of heart.

Fumiya Tomozaki is Japan's best player in the online game Attack Families, commonly known as Tackfam. Despite holding such a revered title, a lack of social skills and amiability causes him to fall short in his everyday high school life. Failing to have any friends, he blames the convoluted mechanics and unfair rules of life, forcing him to give up and proclaim himself a bottom-tier character in this game. After a fateful meeting with another top-tier Tackfam player, Fumiya is shocked to discover the player's true identity—Aoi Hinami, a popular, smart, and sociable classmate who is the complete opposite of himself. Aoi, surprised at how inept Fumiya is at everything besides Tackfam, decides to assist him in succeeding in what she calls the greatest game of them all. Through the gruesome ordeals of social interactions and relationships, Fumiya begins to advance tiers in the glorious game of life.

In 2015 A.D., Dr. Yamanoue, the Secretary of the Science Ministry, who devotes himself assembles the Android robot on an artificial island. He intends to live together with him as his own son. But the robot has a deficiency in his electric brain. He comes to the conclusion that Dr. Kawashimo's help is essential to correct his defective rain. Although they are friends, they are rivals not only in private life but also in scientific study. Dr. Yamanoue is very jingoistic and only thinks of the robot as one of his strategic arms. On the contrary, Dr. Kawashimo is a pacifist and devotes his affection to robots. Dr. Kawashimo hurries to the island on request of Dr. Yamanoue, taking his pretty young daughter Miri with him. Arriving on the island, Dr. Kawashimo sets the electric brain into Jet Mars, a robot boy. Thus Mars comes into the world. Everything is new to Mars and he doesn't know what is good or bad. On the next day he lifts Dr. Kawashimo and Miri up onto the building. When he sees a glint of moisture in Miri's eyes, he has a mysterious feeling in his mind. Then he asks Dr. Yamanoue what it is. He is taught that it is a tear a weak girl sheds, but, a strong man never does. One day, the electric brain of Fainton, another robot, is put out of order. So Fainton goes-on a wild rampage and the island is plunged into a crisis. When the seawater runs into the facilities from the big hole made by Fainton, only Mars stands in amazement and is quite at a loss what to do just then Miri exhibits her ultra ability and covers the big hole. Led by her, Mars also carries a sheet of iron and makes repairs. At last they rescue Dr. Yamanoue and Dr. Kawashimo from being washed by seawater. Miri is the robot made by Dr. Kawashimo. Mars learns how to cry and learns how to perform a kind deed. (Source: Tezuka Production, Toei Animation)

The famous Seven Mysteries that every school seems to have are a staple of Japanese urban legends. One of the most well-known of these tales is that of Hanako-san: the ghost of a young girl who haunts the school's bathrooms. Kamome Academy has its own version of Hanako-san's legend. Rumors claim that if one successfully manages to summon Hanako-san, she will grant her summoner any wish. Lured by the gossip, many people have tried to call upon her, yet every attempt has failed. However, when Nene Yashiro, a girl hoping for romantic fortune, dares to summon Hanako-san, she discovers that the rumored girl is actually a boy! After a series of unfortunate events involving Yashiro's romantic desires, she is unwillingly entangled in the world of the supernatural, becoming Hanako-kun's assistant. Soon, she finds out about Hanako-kun's lesser-known duty: maintaining the fragile balance between mortals and apparitions.