Venus Versus Virus follows regular schoolgirl Sumire who's had the ability to see ghosts since a young age. She tells friends and family about this fact and they just dismiss it, thinking she's a liar. A chance encounter with a broach flying out of nowhere, a monster and gothloli clad monster killer named Lucia leaves her with a life changing decision to use her ability and fight against these viruses feeding upon the human race. (Source: AnimeNewsService)

The story revolves around the members of a private military company (PMC), and the uneasy tension between them and the regular military after a war that caused massive environmental destruction. (Source: Animekon)

The Great War finally came to an end after four long years of conflict; fractured in two, the continent of Telesis slowly began to flourish once again. Caught up in the bloodshed was Violet Evergarden, a young girl raised for the sole purpose of decimating enemy lines. Hospitalized and maimed in a bloody skirmish during the War's final leg, she was left with only words from the person she held dearest, but with no understanding of their meaning. Recovering from her wounds, Violet starts a new life working at CH Postal Services after a falling out with her new intended guardian family. There, she witnesses by pure chance the work of an Auto Memory Doll, amanuenses that transcribe people's thoughts and feelings into words on paper. Moved by the notion, Violet begins work as an Auto Memory Doll, a trade that will take her on an adventure, one that will reshape the lives of her clients and hopefully lead to self-discovery.

Situated on Blue Island, the Manifestation Engine has been the answer to the world's energy problem for five years. On the neighboring island of Izu Ooshima reside the cheerful Akane Isshiki, her dependable little sister Momo, and her grandfather Kenjirou, one of the inventors of the Manifestation Engine. As they live peacefully alongside the powerful creation, it all seems like a dream until mysterious entities known as the Alone appear seeking to destroy it. With military forces failing to repel the invaders, Kenjirou grants Akane a special key containing the Vivid System—empowering her to fight the Alone. Joined by Aoi Futaba, Wakaba Saegusa, and Himawari Shinomiya, Akane and her friends stand together in the battle against the unforeseen enemy as the last hope for humanity.