The series revolve around a team of 12 high school students who love to play the trading card game Rebirth For You. (Source: ANN)

Atsushi Miyagawa is an 11-year-old boy with the appearance of a fully-grown man. His 17-year-old sister, Atsumi, has the stature of a child! From Atsushi being arrested numerous times as a suspected predator to Atsumi constantly grabbed like a small child more times than she can count, many things go wrong for this curious sibling duo. Atsumi's classmate is even in love with Atsushi, oblivious to his true age! Despite all this, indeed, there is not a single dull moment in the Miyagawa household.

Saikin, Imouto no Yousu ga Chotto Okashiinda ga. follows a family just starting to rebuild. When they marry, Mr. and Mrs. Kanzaki bring a teenage son and daughter along for the ride. But high school freshman Mitsuki Kanzaki is less than thrilled. Stinging from a history of absent and abusive father figures, she is slow to accept her stepfather and stepbrother. But after an accident lands Mitsuki in the hospital, she finds herself possessed by the ghost of Hiyori Kotobuki, a girl her age who was deeply in love with Mitsuki's stepbrother Yuuya. Hiyori cannot pass on to her final reward because of her unrequited love for Yuuya, meaning she's got to consummate it... in Mitsuki's body?! Now, Mitsuki's life depends on getting Hiyori to Heaven. But will she get used to sharing herself with a pushy, amorous ghost? Can she overcome her distrust of her new family? Can she bring herself to fulfill Hiyori's feelings for Yuuya? And might she be hiding some feelings of her own?

Hibiki Amami would be a regular high school girl if it weren't for one thing: a sixth sense that allows her to see ghosts. Rather than being scared, Amami is more interested in befriending and helping the apparitions. This often leads to her human friends witnessing paranormal activity as the ghosts try to help Amami with everyday tasks. The majority of Amami's friends accept that she has a sixth sense, but Narumi Inoue—a girl who is terrified of the supernatural—refuses to acknowledge that ghosts are real. Though she is scared and stubborn, Inoue goes along with the rest of her friends, who decide to take up Amami's mission of helping ghosts however they can.