The year is 2006, and the halls of Tokyo Prefectural Jujutsu High School echo with the endless bickering and intense debate between two inseparable best friends. Exuding unshakeable confidence, Satoru Gojou and Suguru Getou believe there is no challenge too great for young and powerful Special Grade sorcerers such as themselves. They are tasked with safely delivering a sensible girl named Riko Amanai to the entity whose existence is the very essence of the jujutsu world. However, the mission plunges them into an exhausting swirl of moral conflict that threatens to destroy the already feeble amity between sorcerers and ordinary humans. Twelve years later, students and sorcerers are the frontline defense against the rising number of high-level curses born from humans' negative emotions. As the entities grow in power, their self-awareness and ambition increase too. The curses unite for the common goal of eradicating humans and creating a world of only cursed energy users, led by a dangerous, ancient cursed spirit. To dispose of their greatest obstacle—the strongest sorcerer, Gojou—they orchestrate an attack at Shibuya Station on Halloween. Dividing into teams, the sorcerers enter the fight prepared to risk everything to protect the innocent and their own kind.

Using high-level plays by strong fighters as its base, the “UNI app” allows beginners to quickly improve their skills and has brought about a drastic change in how Vanguard is played. Cementing its place as a dream program with global appeal, Vanguard has become dominated by the Uniformers. Meanwhile, Masanori schemes in the shadows, the mysterious Shirogane has a string of tournament victories, Halona finally reveals her true capabilities, Sophie continues to hold the title of “The Strongest”, and Jinki aims to create the “ultimate fight” to fulfill his brother’s dying wish. The ideal world envisioned by AI GUI is slowly coming to fruition – a world where everyone and anyone can become the strongest. With the odds stacked against them, Yu-yu and friends must fight to reject this monotonous vision of Vanguard, and strive for the sake of enjoyable cardfights with individuality! (Source: cf-vanguard.com)

After an accident that killed his father and left his sister with a disability, Shun Tokinoya's mental duress has led to him refraining from online gaming. Now a model high school student who feels remorse over his past lifestyle, Shun works part-time in the cybercafe owned by his childhood friend Nozomi Inatsuki in order to support his family. Despite this, an incident pushes Shun back into the world of online gaming. Following the sudden retirement of all players of FOX ONE—Nozomi's father’s esports team—Shun learns that the Inatsuki family is in severe debt. In order to repay the money they owe, Shun reluctantly agrees to participate in an online game tournament: Xaxerion Championship. Joined by their classmate Akito Sendou, the three of them scout for talented players to rebuild the team. Although they are lucky to find two promising additions to FOX ONE, it is too soon to celebrate: if Shun does not let go of his guilty conscience, the makeshift team stands no chance at winning the tournament.

Rebel organization Reunion has reduced the city of Chernobog to ashes and despair. That is only the beginning of its uprising against the nations prejudiced toward those infected with the highly contagious and deadly disease Oripathy. Now, the rebels have set their sights on Lungmen—a prosperous city infamous for its inhumane treatment of the sick. After witnessing Reunion destroy her homeland, Chief Ch'en of the Lungmen Guard Department's Special Inspection Unit leads her squad to defend her city. Meanwhile, Amiya, the Doctor, and the rest of the advanced pharmaceutical company Rhodes Island continue to oppose Reunion on all fronts. However, they soon find themselves in a deadlock against a powerful enemy: FrostNova, a Reunion commander whose fearsome wintry powers cause anyone unfortunate enough to stand in her way to slowly perish in frost.