2035 A.D. The heads of ancient giant idols were excavated all over the world. Using those twelve stones statues, Humanity had barely overcome the threat of extinction called the Equatorial Winter. But the stone statues had forced Humanity to construct colossal suits of armor as their bodies and demanded that the humans fight each other. (Source: ANN)

As Tooru continues on her quest to become the greatest maid and Kanna Kamui fully immerses in her life as an elementary school student, there is not a dull day in the Kobayashi household with mischief being a daily staple. On one such day, however, a massive landslide is spotted on the hill where Kobayashi and Tooru first met—a clear display of a dragon's might. When none of the dragons they know claim responsibility, the perpetrator herself descends from the skies: Ilulu, the radical Chaos Dragon with monstrous power rivaling that of Tooru. Sickened by Tooru's involvement with humans, Ilulu resorts to the typical dragon method of resolving conflict—a battle to the death. Despite such behavior, she becomes intrigued by Kobayashi's ability to befriend dragons and decides instead to observe just what makes Kobayashi so special. With a new troublesome dragon in town, Kobayashi's eccentric life with a dragon maid is only getting merrier.

It has been five years since AI Kizuna disappeared from the virtual world. Despite being an AI, she has captured the hearts of her fans, including Miracle, an aspiring virtual artist, with her performances. As Miracle attends ADEN Academy, a school for virtual artists, she makes new friends while learning more about singing, performing, and streaming. Miracle's ultimate goal is to win the prestigious Lapin d'Or at the Virtual Grid Awards, an achievement Kizuna has earned five consecutive times. To do this, she works to improve her channel ranking through streams and performances, trying to stand out among other students at the academy. Determined to fulfill her dream of inspiring others the same way Kizuna inspired her, the budding star will not give up.

Katsuhira Agata is a quiet and reserved teenage boy whose sense of pain has all but vanished. His friend, Chidori Takashiro, can only faintly remember the days before Katsuhira had undergone this profound change. Now, his muffled and complacent demeanor make Katsuhira a constant target for bullies, who exploit him for egregious sums of money. But their fists only just manage to make him blink, as even emotions are far from his grasp. However, one day Katsuhira, Chidori, and four other teenagers are abducted and forced to join the Kizuna System as official Kiznaivers. Those taking part are connected through pain: if one member is injured, the others will feel an equal amount of agony. These individuals must become the lab rats and scapegoats of an incomplete system designed with world peace in mind. With their fates literally intertwined, the Kiznaivers must expose their true selves to each other, or risk failing much more than just the Kizuna System.