Zenitendo is a mysterious candy store that only lucky people can reach. All the candy recommended by Beniko, the owner of the store, is perfectly suited to the buyer's troubles. However, it depends on whether the candy will be used or eaten correctly that it can bring happiness or misfortune. (Source: MAL News)

Shy, reserved, and small-statured, Deimon High School student Sena Kobayakawa is the perfect target for bullies. However, as a result of running errands throughout his life, Sena has become agile and developed a skill for avoiding crowds of people. After the cunning Youichi Hiruma—captain of the Deimon Devil Bats football team—witnesses Sena's rapid legs in motion, he coerces the timid boy into joining his squad. As Hiruma wants to conceal Sena's identity from other clubs, Sena is forced to hide under the visored helmet of Eyeshield 21, a mysterious running back wearing the number 21 jersey. The legendary Eyeshield 21 can supposedly run at the speed of light and has achieved remarkable feats in the United States during his time at the Notre Dame College. Accustomed to avoiding his problems in the past, Sena's specialty might just help him become the new secret weapon of the Deimon Devil Bats. As he interacts with his teammates, Sena gradually gains more self-confidence and forges valuable bonds along the way.

Recap of first 8 episodes of the second season, narrated by Yuma and Astral.

Action Duels, which allow duelists to soar and swing alongside their Duel Monsters, are taking the world by storm. Due to an evolutionary breakthrough, the Solid Vision system is now able to provide Duel Monsters with mass. Yuuya Sakaki is Yuusho Sakaki's son, the latter being the founder of You Show Duel School in Miami City. Yuusho insists that duels are not a tool of war, but rather are to bring smiles to people and thus introduced the concept of Entertainment Dueling. However, at the height of his fame, Yuusho disappears and fails to attend his duel with Strong Ishijima, the Action Duel champion. Although scarred by this sudden leave, Yuuya vows to become an Entertainment Duelist like his father. Several years later, in the midst of a battle with Strong Ishijima, Yuuya's desperation to win brings forth a miracle. His pendant begins glowing, turning his cards into Pendulum Cards, which enables him to perform a Pendulum Summon—a summoning method unknown to the world and himself—gaining him fame overnight. As a result, Reiji Akaba, CEO of Leo Corporation and founder of the elite Leo Duel School, starts producing new Pendulum Cards to incorporate Pendulum Summoning into the system. Thus, the mysteries that surround Pendulum Summoning and Yuuya's father start to unravel, and Yuuya learns bit by bit what it takes to become an Entertainment Duelist.