Academy City, Japan, is at the forefront of science. Besides being 30 years ahead of the world technologically, more than three-fourths of this peculiar city's population consists of students developing their psychic abilities as espers in various institutions. Among these students is Touma Kamijou, a high school boy with the lowest psychic rank of zero, but with a mysterious power no scientist can understand: Imagine Breaker, which allows him to negate other supernatural abilities. This, however, doesn't affect Kamijou's life in the least as he plays his role as a regular teenager; that is, until he meets the strange Index Librorum Prohibitorum, a young girl who has memorized the entirety of the forbidden grimoires, and now a dangerous organization is hunting Index down. With several magicians looking to harm the girl, Kamijou will defend his new companion at all costs as he discovers a strange new realm of the supernatural.

In the scientifically advanced Academy City, a miracle is about to occur: the completion of the world's first space elevator, Endymion. Meanwhile, a certain high school student, Touma Kamijou, and his companion Index are going about their daily lives when they encounter and befriend Arisa Meigo, a cheerful and ambitious singer. When strange occurrences begin taking place throughout the city, they lead to the discovery of an intricate plot surrounding Arisa and Endymion. Things only get more complicated when the Stiyl Magnus appears, signifying that the magical world is somehow involved too...

Touma Kamijou can't catch a break. After the invasion of Academy City, political tensions continue to rise as both the science and magic factions collide head on. It appears that Academy City intends to declare war against the Roman Catholic Church, consequently plunging the whole world into global warfare. Touma soon finds himself on the front lines once again, striving to protect his friends and allies. Toaru Majutsu no Index III serves as the last installment of the original franchise as Touma, Accelerator, and the true Level 0 Shiage Hamazura continue their separate journeys, leading up to the final act of the original light novel series.

Toradora DVD shorts featuring the miniature forms of the Toradora characters talking about, and eating, food.