Blue Gender takes place in the not too distant future in a world where things have gone terribly wrong for humanity. Humans have been replaced at the top of the food chain by the Blue, a race of bug-like aliens that have colonized Earth and pushed humans aside. A space station, Second Earth, has been constructed as a safe haven for humans, with the hope of one day reclaiming the Earth once more. Yuji Kaido was cryogenically frozen, having been suffering from a disease known as B-Cells. Once awakened, he joins a team of soldiers that have come to Earth to extract him. Unfortunately, nothing goes according to plan as they make their way back to Second Earth. Yuji will have to deal with the horrors of fighting a bloody war as he and the fighters from Second Earth look to survive. Will they be able to win back Earth without losing their humanity?

The story takes place in an alternate reality based in the year 1996, where humanity is advanced enough to develop long-range space travel, as well as bases on both the Moon and Mars. However, the Cold War tensions between the United States and the Soviet Union have not ended; rather, they've escalated as both sides build military facilities in space, and the shadow of nuclear conflict looms over humanity, both on and off Earth. Meanwhile, on the Red Planet, an exchange program created by the United Nations to promote peace and understanding is about to begin; the Cosmic Culture Club, consisting of 16 boys and girls, as well as their instructor Elizabeth, arrives at the UN Mars base. Among the passengers is Anna a 14-year-old girl who serves as the narrator for the story. Suddenly, four unidentified humanoid robots classified as Super Powered Tracers are detected, engaged in fierce combat with each other. The UN base is caught in the crossfire and quickly destroyed, killing all but six members of the Cosmic Culture Club—Elizabeth, Arthur, Roan, David, Simone and Anna, and leaving them stranded on an inhospitable planet that has suddenly become a battlefield. As the battle ends, the lone SPT standing lands next to the terrified group and opens up revealing a pilot, who simply announces to them, Earth is at stake.

This is a different version of the story than the one included in the Seishun Anime Zenshu TV series. Bocchan, a recent graduate, sets out for his first teaching assignment… never anticipating what awaits him. He must contend with students who spy on him and pull nasty stunts and with a landlord who constantly tries to sell him worthless antiques. While on a fishing trip to boost his spirits, Bocchan suspects Hotta, his one friend in the village, as the cause of all of his misery. But this is just beginning of his problems…During a meeting to discuss the students' disrespectful behavior towards Bocchan, the proposed punishment is surprisingly mild despite the severity of the acts. Yet, Bocchan's suspected adversary defends him! Were the other faculty members lying about Hotta? Bocchan may soon discover the truth, for when evidence of the dean’s activities surface, Bocchan and Hotta must team up to corner the dean in his own scandalous game! (Source: ANN)

Staz Charlie Blood is a powerful vampire who rules the Eastern district of Demon World. According to rumors, he is a bloodthirsty and merciless monster, but in reality, Staz is just an otaku obsessed with Japanese culture and completely uninterested in human blood. Leaving the management of his territory to his underlings, Staz spends his days lazing around, indulging in anime, manga, and games. When Fuyumi Yanagi, a Japanese girl, accidentally wanders through a portal leading into the demon world, Staz is overjoyed. But just as he is starting to feel an unusual attraction to her, his territory is attacked, resulting in Fuyumi's untimely death. She turns into a wandering ghost and the crestfallen Staz vows to resurrect her as this would mean being able to travel to the human world, something he has always dreamed of. Blood Lad follows Staz and Fuyumi, soon joined by the spatial magician Bell and the half-werewolf Wolf, as they travel to find a magic that can bring humans back to life.