Shy and timid in nature, 15-year-old Yu-yu Kondou is constantly pressured by his wacky sisters to fulfill their unreasonable requests. One day, they force their brother to crossdress for the sake of their own entertainment, prompting him to run away from home. Following a series of unexpected events, Yu-yu encounters Megumi Ookura, a friendly girl who introduces him to Team Blackout—a group of individuals deeply involved in a card game called Cardfight Vanguard. As he increasingly connects with the members of Team Blackout—Danji Momoyama, Zakusa Ishigame, Tomari Seto, and Megumi herself—Yu-yu discovers a whole new and exciting world, one he could have never imagined without the help of his newfound friends.

Upon the conclusion of the Vanguard High School Koshien, Kouji Ibuki begins to have new nightmares. Nome Tatsunagi has Suiko summon him to the mansion where they learn he can see a Dark Tower called Sanctuary. Sanctuary is causing the timeline to be altered throughout history, and the only way to correct it is for Kouji to first correct his future mistake. Now Kouji and Suiko must travel the parallel world -if- and watch as Magical Girls Emi Sendou and Shuka summon Vanguard units to help correct history. Sadly, the two can't help much, as Cardfighting against real monsters doesn't do much good. (Source: ANN)

It has been 50 years since mankind began its migration to the terraformed Mars, where they live in comfort due to advancements in AI. Carole lives in the metropolis of Alba City, working part-time by day and playing keyboard by night. Tuesday has run away from her home in Hershell City to escape the grip of her wealthy family, and instead hopes to pursue music with her acoustic guitar. After a fateful encounter, the two decide to perform music together. Up against the AI singers that dominate the music world, the two of them believe that together they can convey their feelings through their songs. Will hard work and luck be enough for the duo to create the biggest miracle that Mars has ever seen?

Taking the world by storm, the card game Cardfight Vanguard has influenced many to integrate card games into their everyday lives. Players of the popular game are called cardfighters, and they frequently battle each other in card shops. The game has inspired many people, one of which is the quiet and timid Aichi Sendou who is often ridiculed and bullied by his peers. Whenever he feels down, he takes a glance at Blaster Blade—a legendary rare card given to him when he was young—and gains the motivation to move on with his life. However, one day, school bully Katsumi Morikawa notices Aichi's treasure and snatches the card away from him. After a turn of events, Aichi soon discovers that the card is now in the hands of Toshiki Kai, a cardfighter who has become the strongest in town despite having only recently arrived. To make matters worse, Kai refuses to return the card unless Aichi defeats him in a cardfight. Much to everyone's surprise, Aichi rises up to the occasion. As he musters up his courage and pictures himself winning this decisive battle, Aichi begins to find his way into the adventurous world of Cardfight Vanguard.