Vash the Stampede is the man with a $$60,000,000,000 bounty on his head. The reason: he's a merciless villain who lays waste to all those that oppose him and flattens entire cities for fun, garnering him the title The Humanoid Typhoon. He leaves a trail of death and destruction wherever he goes, and anyone can count themselves dead if they so much as make eye contact—or so the rumors say. In actuality, Vash is a huge softie who claims to have never taken a life and avoids violence at all costs. With his crazy doughnut obsession and buffoonish attitude in tow, Vash traverses the wasteland of the planet Gunsmoke, all the while followed by two insurance agents, Meryl Stryfe and Milly Thompson, who attempt to minimize his impact on the public. But soon, their misadventures evolve into life-or-death situations as a group of legendary assassins are summoned to bring about suffering to the trio. Vash's agonizing past will be unraveled and his morality and principles pushed to the breaking point.

Kenjaku, the one known as Noritoshi Kamo and most recently as Suguru Getou, has initiated the next step in his destructive, thousand-year plan of ordinary humans' evolution and eventual eradication. The jujutsu world higher-ups reinstate 15-year-old Yuuji Itadori's execution, as Satoru Gojou is incapacitated as a result of Kenjaku's master plan in Shibuya. While Yuuji is unaware of this, he patrols the abandoned Tokyo streets with Chousou, exterminating any and all cursed spirits in his way. Meanwhile, the bigoted and arrogant Naoya Zenin's pride takes a hit when Megumi Fushiguro is selected as the Zenin Clan's next head. To draw out Megumi and eliminate him, he goes after Yuuji—but Yuuta Okkotsu is set on being Yuuji's executioner. Kenjaku's Culling Game—a rigorous battle royale spanning throughout Japan and forcing the jujutsu competitors to kill each other—is set in motion, and the young jujutsu sorcerers join the fray to settle old scores, free Gojou, and liberate the jujutsu world from the threat that is Kenjaku.

Every morning, incoming first-year Taiki Inomata hurries to his high school gym in order to further refine his badminton skills. However, his true motivation stems from sharing the otherwise empty gym with second-year Chinatsu Kano, Taiki's crush and the star player of the girls' basketball team. Although Chinatsu seems unapproachable, Taiki gradually finds opportunities to get to know her little by little. Unbeknownst to Taiki, his tireless work ethic and admiration motivate Chinatsu to work harder and strive to achieve her greatest ambitions. When her family must suddenly move overseas for work, Chinatsu decides to remain in Japan and shoot for victory at the national level. With nowhere to stay, she is taken in by Taiki's mother, who is longtime friends with Chinatsu's own. Overwhelmed with the new reality of living alongside the girl he loves, Taiki resolves to join Chinatsu at the national level in his own sport—and grow closer to her in the process. Still, despite being good enough to catch his coach's eye, Taiki must fight an uphill battle to qualify for a spot on the starting team. Cheered on by both Chinatsu and gymnast Hina Chouno, his childhood friend, Taiki aims to make a name for himself among his powerful upperclassmen.

In the studio of the morning childrens' show Together with Mama, a crew of miserable adults prepares their facades of amicable smiles and cheerful exteriors to educate a group of innocent preschoolers. In the middle of it stands Uramichi Omota, a former gymnast who can't help but bring the kids down to earth by revealing the harsh and depressing reality of adulthood, even in front of the rolling cameras. Behind the scenes, Uramichi's much-desired peace is disturbed by his two bothersome juniors who work as the show's rabbit and bear mascots and singers: Utano Tadano, a woman who only wishes to get married; and Iketeru Daga, a handsome man with a crass sense of humor. From smoking and exercising to nihilistic outbursts, everyone's big brother Uramichi always brings up the not-so-moral side to his life lessons.