Usagi Tsukino is still struggling to balance her home life with the duties of being Sailor Moon, the guardian of love and justice. Along with the other Sailor Guardians and her boyfriend Mamoru Chiba, they begin investigating cases of students from Mugen Academy, a school for the most elite students, who are being transformed into monsters. During the investigation, they meet three strange individuals: Haruka Tenou, a handsome racecar driver; Michiru Kaiou, a talented violinist; and Hotaru Tomoe, a mysterious girl with a weak constitution. As more incidents occur, the Sailor Guardians are met with another surprise—the appearance of two new planetary protectors with motives of their own. Despite the newcomers' questionable allegiance to Usagi and her comrades, they all face a threat from a common enemy: an evil entity who calls himself Pharaoh 90.

Sixth grader Sana Kurata has a perfect life. Her mother is a (fairly) successful author, she has a young man employed to keep her happy and safe, and best of all, she is the star of the children's television show Kodomo no Omocha. There's just one thing bothering her, and that's Akito Hayama. Akito is a classmate of Sana's, and ever since he's started acting out in class, the rest of the boys have followed his example. Every day, the girls and the teacher wage a battle to keep the class under control and to get some actual learning done. That rotten Akito… Sana won't stand for this! The hyperactive Sana decides to dig deeper and find out what makes Akito tick, so class can go back to normal and the teacher can stop spending every day crying instead of teaching. But the more she learns about him, the more she realizes that there might be more to Akito than meets the eye.

Private detective Sousuke Kaburaya is simply trying to make ends meet when Sara da Odin, an imperial princess from another world, falls through a portal right on top of him. Unaware that she is an anomaly in a magicless world, Sara uses powerful spells in public, causing a commotion and forcing Sousuke to take her back home with him. With the help of the internet, manga, and modern Japanese conveniences, Sara grows accustomed to living in Japan and becomes Sousuke's assistant in the process. Meanwhile, Livia de Udis, Sara's personal knight, also comes through the portal but lands at a different location. There, she meets a homeless man who readily accepts her unique background and odd tendencies. Despite her situation, Livia quickly adapts and settles into the homeless lifestyle, a far cry from the noble position she used to hold. While Sara and Livia may be living different lives, their positive and ambitious attitudes leave a lasting impact on the people around them as they experience both the good and bad of Japan.

Takashi Natsume and his spirit companion Madara, nicknamed Nyanko, continue returning the names of spirits from the Book of Friends given by his late grandmother Reiko Natsume. On his way back from school one day, Takashi encounters a lurking spirit named Monmonbou, who recalls memories of Takashi's grandmother after hearing his name. Takashi's natural curiosity leads him to explore a mysterious town where his grandmother used to live. Befriending her old acquaintance Yorie Tsumura and Yorie's son Mukuo, Takashi unveils more of his grandmother's past. In the meantime, Nyanko detours for food and stumbles upon a suspicious Spirit Seed, which miraculously sprouts into a fruit tree overnight. Giving in to temptation, Nyanko consumes the fruit, splitting him into three. Seeking a solution to Nyanko's predicament, Takashi and his friends lend a hand, unexpectedly uncovering more secrets the town holds in the process.